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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Placental and oral delivery of Schistosoma mansoni antigen from infected mothers to their newborns and children.
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Placental and oral delivery of Schistosoma mansoni antigen from infected mothers to their newborns and children.

机译：曼氏血吸虫曼沙尼抗原从受感染的母亲向其新生儿和儿童的胎盘和口服递送。

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摘要

A 63-kD Schistosoma mansoni antigen was detected in 149 (86%) of 174 umbilical cord blood sera from infected women at delivery. Specific IgG antibodies to this antigen were also detected in 80% of cord blood sera. The 63-kD antigen showed the same molecular mass by Western blotting when isolated from cord blood, maternal blood, breast milk, and urine from women infected with S. mansoni. This antigen was detected in the urine of 25 infants born to infected mothers and followed for 18-24 months after delivery. It was also detected in some infants up to 21 days after parturition and then disappeared at 28 days, demonstrating the influence of breast-feeding on persistence of antigen in infants born to infected women. Thus, exposure to Schistosoma antigens and maternal antibodies to this organism may influence the developing immune responses to natural infection or vaccination of children born in endemic areas.
机译：在分娩时，在来自受感染妇女的174脐带血血清中的149（占86％）中检测到63 kD曼氏血吸虫抗原。在80％的脐血血清中也检测到了针对该抗原的特异性IgG抗体。当从感染曼氏沙门氏菌的妇女的脐带血，母血，母乳和尿液中分离出63 kD抗原时，通过蛋白质印迹法显示出相同的分子量。在感染母亲的25例婴儿的尿液中检测到该抗原，并在分娩后随访18-24个月。在分娩后直至21天的某些婴儿中也检测到了这种现象，然后在28天时消失了，这表明母乳喂养对感染妇女出生的婴儿中抗原持久性的影响。因此，暴露于该生物的血吸虫抗原和母源抗体可能会影响对流行地区出生的儿童的自然感染或疫苗接种的免疫反应。

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