• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Genetic relationships among Mayaro and Una viruses suggest distinct patterns of transmission.
【24h】

Genetic relationships among Mayaro and Una viruses suggest distinct patterns of transmission.

机译：Mayaro和Una病毒之间的遗传关系表明了不同的传播方式。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Mayaro and Una viruses (MAYV, UNAV) are mosquito-borne alphaviruses that may cause an acute febrile illness characterized by headache, retro-orbital pain, and rash that may progress to a severe and prolonged arthralgia. MAYV was first isolated in Trinidad in 1954, and UNAV was first identified in northern Brazil in 1959. Since then, numerous isolates of these agents have been made from humans, wild vertebrates, and mosquitoes in several countries in northern South America. Serological evidence suggests that these viruses are also present in portions of Central America. Because little is known about the natural transmission cycle of MAYV and virtually nothing is known about UNAV transmission, 63 isolates covering the known geographic and temporal ranges were used in phylogenetic analyses to aid in understanding the molecular epidemiology. Approximately 2 kb from the E1 and E2 glycoprotein genes and the complete 3' non-coding region were sequenced. Phylogenetic analyses of these sequences indicated that two distinct genotypes of MAYV exist with a distinct clade consisting exclusively of UNAV (previously designated as a subtype of MAYV). One MAYV genotype (genotype D) contains isolates from Trinidad and the northcentral portion of South America including Peru, French Guiana, Surinam, Brazil, and Bolivia. All of these isolates are highly conserved with a nucleotide divergence of < 6%. The second MAYV genotype (genotype L) contains isolates only from Brazil that are highly conserved (< 4% nucleotide divergence) but are quite distinct (15-19%) from the first genotype isolates. These analyses provide possible explanations for the natural ecology and transmission of MAYV and UNAV.
机译：Mayaro和Una病毒（MAYV，UNAV）是由蚊子传播的甲病毒，可能引起急性发热性疾病，其特征为头痛，眼眶后疼痛和皮疹，可能发展为严重的长时间关节痛。 MAYV于1954年在特立尼达首次分离，UNAV于1959年在巴西北部首次被发现。此后，在南美北部几个国家，从人类，野生脊椎动物和蚊子中分离出了许多这种病原体。血清学证据表明，这些病毒也存在于中美洲部分地区。由于对MAYV的自然传播周期知之甚少，而对UNAV的传播几乎一无所知，因此在系统发育分析中使用了63种覆盖已知地理和时间范围的分离株有助于了解分子流行病学。从E1和E2糖蛋白基因以及完整的3'非编码区大约测序了2 kb。这些序列的系统发育分析表明，存在两种不同的MAYV基因型，其独特的进化枝仅由UNAV组成（先前指定为MAYV的亚型）。一种MAYV基因型（基因型D）包含特立尼达和南美中北部地区的分离株，包括秘鲁，法属圭亚那，苏里南，巴西和玻利维亚。所有这些分离株均高度保守，核苷酸差异小于6％。第二个MAYV基因型（基因型L）仅包含高度保守（<4％核苷酸差异）但与第一个基因型分离株截然不同（15-19％）的巴西分离株。这些分析为MAYV和UNAV的自然生态学和传播提供了可能的解释。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号