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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Salivary gland extracts of culicoides sonorensis inhibit murine lymphocyte proliferation and no production by macrophages.
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Salivary gland extracts of culicoides sonorensis inhibit murine lymphocyte proliferation and no production by macrophages.

机译：苦瓜的唾液腺提取物可抑制鼠淋巴细胞的增殖，而巨噬细胞则不产生。

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摘要

Culicoides biting midges serve as vectors of pathogens affecting humans and domestic animals. Culicoides sonorensis is a vector of several arboviruses in North American that cause substantial economic losses to the US livestock industry. Previous studies showed that C. sonorensis saliva, like the saliva of many hematophagous arthropods, contains numerous pharmacological agents that affect hemostasis and early events in the inflammatory response, which may enhance the infectivity of Culicoides-borne pathogens. This paper reports on the immunomodulatory properties of C. sonorensis salivary gland extracts on murine immune cells and discusses the possible immunomodulatory role of C. sonorensis saliva in vesicular stomatitis virus infection of vertebrate hosts. Splenocytes treated with C. sonorensis mitogens were significantly affected in their proliferative response, and peritoneal macrophages secreted significantly less NO. A 66-kDa glycoprotein was purified from C. sonorensis salivary gland extract, which may be in part responsible for these observations and may be considered as a vaccine candidate.
机译：库蚊咬是影响人类和家畜的病原体的载体。 Culicoides sonorensis是北美几种虫媒病毒的载体，这些病毒对美国畜牧业造成了巨大的经济损失。先前的研究表明，C。sonorensis唾液像许多食血节肢动物的唾液一样，含有许多影响止血和炎症反应早期事件的药理剂，这些药理作用可能会增强由库里科德斯氏菌传播的病原体。本文报道了C. sonorensis唾液腺提取物对小鼠免疫细胞的免疫调节特性，并讨论了C. sonorensis唾液在脊椎动物宿主水泡性口炎病毒感染中的可能免疫调节作用。用C. sonorensis丝裂原处理的脾细胞的增殖反应受到显着影响，腹膜巨噬细胞分泌的NO明显减少。从sonorensis唾液腺提取物中纯化了一个66 kDa的糖蛋白，这可能部分负责这些观察结果，并且可以被视为候选疫苗。

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