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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Geographical distribution of hantaviruses in Thailand and potential human health significance of Thailand virus.
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Geographical distribution of hantaviruses in Thailand and potential human health significance of Thailand virus.

机译：泰国汉坦病毒的地理分布以及泰国病毒对人类健康的潜在意义。

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Phylogenetic investigations, sequence comparisons, and antigenic cross-reactivity studies confirmed the classification of Thailand virus (THAIV) as a distinct hantavirus species. The examination of sera from 402 rodents trapped in 19 provinces of Thailand revealed that five greater bandicoot rats (Bandicota indica) and one lesser bandicoot rat (B. savilei) from four provinces were focus reduction neutralization test (FRNT) antibody-positive for THAIV. One of 260 patients from Surin province in Thailand (initially suspected of having contracted leptospirosis, but found to be negative) showed symptoms compatible with hemorrhagic fever with renal syndrome (HFRS). The serum of this patient showed high titers of hantavirus-reactive IgM and IgG. FRNT investigations confirmed virus-neutralizing antibodies against THAIV. These observations suggest that THAIV or THAI-like viruses occur throughout Indochina and may represent an additional causative agent of HFRS.
机译：系统发育研究，序列比较和抗原交叉反应性研究证实了泰国病毒（THAIV）属于独特的汉坦病毒种类的分类。对来自泰国19个省的402只啮齿类动物的血清进行的检查显示，来自四个省的5只大白鼬大鼠（Bandicota indica）和一只小白鼬大鼠（B. savilei）对THAIV的减毒中和试验（FRNT）抗体呈阳性。来自泰国素林省的260名患者中的一名（最初怀疑患有钩端螺旋体病，但被发现为阴性）表现出与肾综合征出血热（HFRS）相适应的症状。该患者的血清显示高滴度的汉坦病毒反应性IgM和IgG。 FRNT调查证实了针对THAIV的病毒中和抗体。这些观察结果表明，THAIV或THAI样病毒遍布印度支那，可能是HFRS的另一种致病因子。

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