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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Pathogenesis of West Nile virus infection in dogs treated with glucocorticoids.
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Pathogenesis of West Nile virus infection in dogs treated with glucocorticoids.

机译：用糖皮质激素治疗的狗中西尼罗河病毒感染的发病机理。

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摘要

Control and glucocorticoid-treated dogs were infected with West Nile virus (WNV) through the bites of infected mosquitoes to study the effect of a commonly used immunomodulator on the magnitude and duration of viremia and on development of clinical disease. All dogs became viremic after challenge. The peak viremia and integrated magnitude of viremia were approximately 40 and 50 times higher, respectively, in the five dogs treated with methyl-prednisolone for 1 month compared with untreated dogs. None of the five control or treated dogs developed signs of clinical disease, nor was histopathologic evidence of neuroinvasion observed in any case. Neutralizing antibodies to WNV were produced in all dogs, with no apparent effect of glucocorticoid treatment. Considering the dramatic effect of glucocorticoid treatment on magnitude of viremia, it is likely that this therapy had suppressive effects on some aspect of innate immunity or T cell function.
机译：对照组和糖皮质激素治疗犬通过被感染的蚊虫叮咬感染了西尼罗河病毒（WNV），以研究常用免疫调节剂对病毒血症的程度和持续时间以及对临床疾病发展的影响。挑战后所有狗都变成病毒血症。与未治疗的狗相比，用甲基泼尼松龙治疗1个月的五只狗的峰值病毒血症和病毒血症的综合程度分别高大约40倍和50倍。五只对照犬或治疗犬均未出现临床疾病迹象，在任何情况下均未观察到神经浸润的组织病理学证据。在所有狗中产生针对WNV的中和抗体，没有糖皮质激素治疗的明显作用。考虑到糖皮质激素治疗对病毒血症程度的巨大影响，这种治疗可能对先天免疫或T细胞功能的某些方面具有抑制作用。

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