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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Chinese herbal medicine Yin-Chen-Extract as an adjunct to anthelmintic albendazole used against angiostrongylus cantonensis-induced eosinophilic meningitis or meningoencephalitis.
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Chinese herbal medicine Yin-Chen-Extract as an adjunct to anthelmintic albendazole used against angiostrongylus cantonensis-induced eosinophilic meningitis or meningoencephalitis.

机译：中草药茵陈提取物作为驱虫药阿苯达唑的辅助剂，可用于治疗广州圆管虫引起的嗜酸性脑膜炎或脑膜脑炎。

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摘要

The effects of albendazole and Yin-Chen-Extract co-therapy on Angiostrongylus cantonensis-induced eosinophilic meningitis in BALB/c mice were evaluated. Assay indicators for the therapeutic effect include worm recovery, histopathological score of the fourth ventricle, tissue-type plasminogen activator, urokinase-type plasminogen activator, matrix metalloproteinase-9, cerebrospinal fluid total protein, leukocyte counts, and proinflammatory cytokines. As a result, albendazole and Yin-Chen-Extract co-therapy significantly decreased (P < 0.05) these factors. Although Yin-Chen-Extract may possess pharmacologic activities beneficial to the inhibition of parasite-induced inflammation, many of these hypothetical benefits await scientific testing and confirmation before application. This study suggests that the combination of Yin-Chen-Extract and albendazole has synergistic effects in managing eosinophilic meningitis or eosinophilic meningoencephalitis.
机译：评估了阿苯达唑和茵陈提取物联合疗法对BALB / c小鼠广州管圆线虫诱发的嗜酸性粒细胞性脑膜炎的影响。治疗效果的测定指标包括蠕虫恢复，第四脑室的组织病理学评分，组织型纤溶酶原激活物，尿激酶型纤溶酶原激活物，基质金属蛋白酶9，脑脊髓液总蛋白，白细胞计数和促炎细胞因子。结果，阿苯达唑和茵陈提取物联合治疗显着降低了这些因素（P <0.05）。尽管茵陈提取物可能具有有益于抑制寄生虫诱发的炎症的药理活性，但在应用之前，许多假想的益处尚待科学测试和确认。这项研究表明，尹陈提取物和阿苯达唑的组合在治疗嗜酸性脑膜炎或嗜酸性脑膜脑炎方面具有协同作用。

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