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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Experimental infection of Culex annulirostris, Culex gelidus, and Aedes vigilax with a yellow fever/Japanese encephalitis virus vaccine chimera (ChimeriVax-JE).
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Experimental infection of Culex annulirostris, Culex gelidus, and Aedes vigilax with a yellow fever/Japanese encephalitis virus vaccine chimera (ChimeriVax-JE).

机译：黄热病/日本脑炎病毒疫苗嵌合体（ChimeriVax-JE）对库蚊，库蚊和白纹伊蚊的实验性感染。

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摘要

Australian mosquitoes from which Japanese encephalitis virus (JEV) has been recovered (Culex annulirostris, Culex gelidus, and Aedes vigilax) were assessed for their ability to be infected with the ChimeriVax-JE vaccine, with yellow fever vaccine virus 17D (YF 17D) from which the backbone of ChimeriVax-JE vaccine is derived and with JEV-Nakayama. None of the mosquitoes became infected after being fed orally with 6.1 log(10) plaque-forming units (PFU)/mL of ChimeriVax-JE vaccine, which is greater than the peak viremia in vaccinees (mean peak viremia = 4.8 PFU/mL, range 0-30 PFU/mL of 0.9 days mean duration, range of all three species of mosquito became infected when fed on JEV-Nakayama, but only Ae. vigilax was infected when fed on YF 17D. The results suggest that none of these three species of mosquito are likely to set up secondary cycles of transmission of ChimeriVax-JE in Australia after feeding on a viremic vaccinee.
机译：评估了从日本乙型脑炎病毒（JEV）中已恢复的澳大利亚蚊子（无蚊，库蚊和白纹伊蚊）感染ChimeriVax-JE疫苗和黄热病疫苗病毒17D（YF 17D）的能力。是ChimeriVax-JE疫苗的骨干来源，又是JEV-Nakayama。口服喂食ChimeriVax-JE疫苗的6.1 log（10）噬菌斑形成单位（PFU）/ mL时，没有一个蚊子被感染，该值大于被接种者的峰值病毒血症（平均峰值病毒血症= 4.8 PFU / mL，平均持续时间为0.9天的0-30 PFU / mL范围，当以JEV-中山为食时，这三种蚊子的范围均被感染，但是，当以YF 17D食时，仅被感染了吉拉伊蚊。以病毒疫苗为食后，澳大利亚的蚊子可能会建立ChimeriVax-JE的传播第二周期。

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