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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >High titers of IgG antibodies against Plasmodium falciparum serine repeat antigen 5 (SERA5) are associated with protection against severe malaria in Ugandan children.
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High titers of IgG antibodies against Plasmodium falciparum serine repeat antigen 5 (SERA5) are associated with protection against severe malaria in Ugandan children.

机译：高滴度的抗恶性疟原虫丝氨酸重复抗原5（SERA5）IgG抗体与乌干达儿童中预防严重疟疾有关。

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摘要

Plasmodium falciparum serine repeat antigen (SERA5) is a promising asexual blood stage malaria candidate vaccine. However, there is a paucity of information about natural immune responses to SERA5 in children from malaria-endemic regions. We undertook a hospital-based case-control study of severe malaria in Apac District, Northern Uganda, in children 6-59 months of age. The commonest symptoms observed in children with severe malaria (SM) were respiratory distress (53.4%) and prostration (40.4%) followed by circulatory collapse (7.4%), severe anemia (Hb < 5 g/dL, 7.0%), and seizures (2.6%). None of the SM children had impaired consciousness, coma, or cerebral malaria. We measured serum IgG antibodies using a recombinant construct of SERA5 (SE36) in enzyme-linked immunosorbent assays. High titers of IgG anti-SE36 were associated with protection against severe malaria in children under 5 years old.
机译：恶性疟原虫丝氨酸重复抗原（SERA5）是一种有前途的无性血液阶段疟疾候选疫苗。但是，关于来自疟疾流行地区的儿童对SERA5的天然免疫应答的信息很少。我们在乌干达北部Apac地区对6至59个月大的儿童进行了一项针对严重疟疾的医院病例对照研究。在患有严重疟疾（SM）的儿童中观察到最常见的症状是呼吸窘迫（53.4％）和虚脱（40.4％），然后是循环衰竭（7.4％），严重贫血（Hb <5 g / dL，7.0％）和癫痫发作（2.6％）。没有一个SM儿童有意识障碍，昏迷或脑疟疾。我们在酶联免疫吸附测定中使用SERA5（SE36）的重组构建体测量了血清IgG抗体。高滴度的抗SE36 IgG抗体可预防5岁以下儿童患严重疟疾。

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