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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Lack of inhibition of the anti-malarial action of sulfadoxine-pyrimethamine by folic acid supplementation when used for intermittent preventive treatment in Gambian primigravidae.
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Lack of inhibition of the anti-malarial action of sulfadoxine-pyrimethamine by folic acid supplementation when used for intermittent preventive treatment in Gambian primigravidae.

机译：叶酸补充冈比亚的primigravidae的间歇性预防治疗时，缺乏对磺胺多辛-乙胺嘧啶的抗疟疾作用的抑制。

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摘要

Folic acid is frequently given to pregnant women at the same time as intermittent preventive treatment (IPTp) with sulfadoxine/pyrimethamine (SP), but it is not known if it interferes with the anti-malarial activity of SP. To investigate this concern, 1,035 Gambian primigravidae were randomized to receive either folic acid (500-1,500 microg/day) together with oral iron (522) or oral iron alone (513) for 14 days at the same time as they received IPTp with SP. On presentation, 261 women (25%) had Plasmodium falciparum asexual parasitemia. Prevalences of parasitemia on day 14 after treatment were similar in both groups: 5.7% (26 of 458) in the iron plus folic acid group and 4.9% (22 of 446) in the iron alone group (risk difference = 0.74%, 95% confidence interval [CI] = -2.2% to 3.7%). Parasitologic cure was observed in 116 (91%) of 128 of women who were parasitemic on presentation and who received iron and folic acid and in 122 (92%) of 133 women who received iron alone (difference = 1.1%, 95% CI = -5.6%to 8.0%). Women who received folic acid and iron had a slightly higher mean hemoglobin concentration at day 14 than women who had received iron alone (difference = 0.14 g/dL, 95% CI = 0.01-0.27 g/dL). The results of this study suggest that in an area of low SP resistance, administration of folic acid to pregnant women in a dose of 500-1,500 mug/day will not interfere with the protective effect of SP when used for IPTp.
机译：叶酸经常与磺胺多辛/乙胺嘧啶（SP）一起进行间歇性预防治疗（IPTp），同时给孕妇服用，但尚不清楚叶酸是否会干扰SP的抗疟疾活性。为了调查这种担忧，在他们接受SP的IPTp治疗的同时，将1,035名冈比亚初生婴儿随机接受14天叶酸（500-1,500微克/天）以及口服铁（522）或单独口服铁（513）接受14天。介绍时，有261名女性（占25％）患有恶性疟原虫无性寄生虫病。两组在治疗后第14天的寄生虫病患病率相似：铁加叶酸组为5.7％（458个中的26个），铁单独组为4.9％（446个中的22个）（风险差异= 0.74％，95％）置信区间[CI] = -2.2％至3.7％）。出现寄生虫病并接受铁和叶酸的128名妇女中有116名（91％）接受了寄生虫学治愈，仅接受铁酸盐的133名妇女中的122名（92％）中观察到了寄生虫治愈（差异= 1.1％，95％CI = -5.6％至8.0％）。与单独接受铁剂的妇女相比，接受叶酸和铁剂的妇女在第14天的平均血红蛋白浓度略高（差异= 0.14 g / dL，95％CI = 0.01-0.27 g / dL）。这项研究的结果表明，在低SP抗性的地区，以500-1,500马克杯/天的剂量向孕妇施用叶酸不会干扰SP用于IPTp时的保护作用。

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