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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Congenital Chagas disease in Bolivia is not associated with DNA polymorphism of Trypanosoma cruzi.
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Congenital Chagas disease in Bolivia is not associated with DNA polymorphism of Trypanosoma cruzi.

机译：玻利维亚的先天性恰加斯病与克氏锥虫的DNA多态性无关。

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摘要

This study aims to typify the Trypanosoma cruzi (sub)lineage(s) in umbilical cord blood of congenitally infected Bolivian newborns, using PCR amplifications of "Region Markers", mini-exon or kDNA fragments followed by hybridization or sequencing. New probes were also designed to distinguish three variants within the TcIId sublineage. The IIb, IId, or IIe T. cruzi sublineages, as well as different variants of the IId sublineage, were detected in infected neonates, whereas mixed infections were not found. The frequencies of the IId sublineage were similar in neonates (95.1%) and adults of the same area (94.1%). The IId-infected newborns displayed either asymptomatic, or severe and fatal clinical forms of congenital Chagas disease, as well as low or high parasitemia. Altogether these data show that T. cruzi DNA polymorphism, based on the presently available markers, is not associated with the occurrence of congenital infection or the development of severe clinical forms of congenital Chagas disease.
机译：这项研究的目的是使用“区域标记”，mini-exon或kDNA片段的PCR扩增，然后进行杂交或测序，对先天感染的玻利维亚新生儿脐带血中的锥虫锥虫亚种进行分类。还设计了新的探针以区分TcIId亚谱系内的三个变体。在感染的新生儿中检出了IIb，IId或IIe克鲁维酵母亚种，以及IId亚种的不同变体，但未发现混合感染。 IId子系的频率在新生儿（95.1％）和同一地区的成年人（94.1％）中相似。 IId感染的新生儿表现出先天性恰加斯病无症状，严重或致命的临床形式，以及低或高寄生虫病。总而言之，这些数据表明，基于目前可利用的标记，克鲁维氏锥虫DNA多态性与先天性感染的发生或先天性恰加斯病的严重临床形式的发展无关。

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