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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Population dynamics of an endogenous meiotic drive system in Aedes aegypti in Trinidad.
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Population dynamics of an endogenous meiotic drive system in Aedes aegypti in Trinidad.

机译：特立尼达埃及伊蚊内源性减数分裂驱动系统的种群动态。

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摘要

An endogenous meiotic drive system was previously reported to be segregating in the yellow fever mosquito Aedes aegypti L. (Diptera: Culicidae) population in Trinidad. The meiotic driver (M(D)) is tightly linked to the male determining locus and selectively targets sensitive responders linked to the female determining allele, causing fragmentation of female gametes. This results in highly male-biased progeny. The M(D) system was initially studied as a genetic tool for population control with limited success, but recently interest has focused on its potential for population replacement. This study examines the distribution and dynamics of the M(D) system in Trinidad natural populations. We obtained ovitrap samples from seven geographically distinct regions and determined the allele frequencies of the driver (M(D)) and sensitive (m(s)) versus insensitive (m(i)) responders, respectively. Frequencies of the M(D) allele ranged from 0.1 to 0.5 and were low at the two major port cities, Port of Spain and San Fernando, suggesting the effects of frequent immigration by non-driving genotypes. Frequencies of the m(i) allele ranged from 0.4 to 0.7, suggesting the effects of strong selection by the driver. In addition, our results show that the driver and sensitivity of responders in the Trinidad populations are highly polymorphic. Continued studies of the dynamics of the M(D) system in natural populations are critical to considerations of its use in population replacement.
机译：以前据报道，内特异的减数分裂驱动系统在特立尼达的黄热蚊Aedes aegypti L.（Diptera：Culicidae）种群中隔离。减数分裂驱动子（M（D））与雄性决定基因座紧密相连，并选择性地靶向与雌性决定等位基因相连的敏感反应者，导致雌性配子分裂。这导致高度男性偏爱的后代。 M（D）系统最初是作为人口控制的遗传工具进行研究的，但收效甚微，但最近的兴趣集中在其人口替代的潜力上。这项研究检查了特立尼达自然种群中M（D）系统的分布和动力学。我们从七个地理上不同的地区获得了卵捕获样品，并分别确定了驱动程序（M（D））和敏感（m（s））与不敏感（m（i））响应者的等位基因频率。 M（D）等位基因的频率范围从0.1到0.5，在两个主要港口城市西班牙港和圣费尔南多均很低，这表明非驾驶基因型频繁移民的影响。 m（i）等位基因的频率介于0.4到0.7之间，表明驾驶员强烈选择的效果。此外，我们的结果表明，特立尼达人群中反应者的驱动因素和敏感性高度多态。对自然种群中M（D）系统动力学的持续研究对于在种群替代中使用它的考虑至关重要。

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