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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Mathematical model of the first wave of Plasmodium falciparum asexual parasitemia in non-immune and vaccinated individuals.
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Mathematical model of the first wave of Plasmodium falciparum asexual parasitemia in non-immune and vaccinated individuals.

机译：非免疫和接种疫苗的个体中第一轮恶性疟原虫无性寄生虫的数学模型。

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摘要

We present a dynamic model of the highly pathogenic first wave of Plasmodium falciparum asexual parasitemia in non-immune persons. The model was successfully fitted to malaria therapy data. This required four case-specific parameters: the basic two-day multiplication factor, the time of onset of adaptive immunity, and the effective dose 50 densities for the innate and adaptive immune responses, respectively. All four parameters show large case-dependent variation that is mainly attributable to host factors. According to the model, the maximum value of the first wave is controlled mainly by the innate immune response. We used the model to explore the expected effects of vaccines targeting the parasite's asexual blood stages on the basis of what we consider to be the biologically most plausible assumptions concerning the parameter modifications induced by vaccination. According to our simulations, the benefit of antiparasitic vaccination is strongly host dependent and vaccine efficacy at low immunogenicity is much larger against severe disease than against fever. This has implications for the early testing of the protective efficacy of a vaccine in humans.
机译：我们提出了在非免疫人群中恶性疟原虫无性寄生虫高致病性第一波的动态模型。该模型已成功拟合疟疾治疗数据。这需要四个案例特定的参数：基本的两天乘法因子，适应性免疫的发作时间以及分别用于先天和适应性免疫反应的有效剂量50密度。所有这四个参数均显示出与案例有关的较大差异，这主要归因于宿主因素。根据该模型，第一波的最大值主要由先天免疫反应控制。我们使用该模型，在我们认为是关于疫苗诱导的参数修饰的生物学上最合理的假设的基础上，探索了针对寄生虫无性血液阶段的疫苗的预期效果。根据我们的模拟，抗寄生虫疫苗的益处在很大程度上取决于宿主，并且针对严重疾病的疫苗在低免疫原性下的功效要远大于对发烧的功效。这对疫苗在人类中的保护功效的早期测试具有影响。

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