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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Critical evaluation of different methods for measuring the functional activity of antibodies against malaria blood stage antigens.
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Critical evaluation of different methods for measuring the functional activity of antibodies against malaria blood stage antigens.

机译：评估评估抗疟疾血阶段抗原抗体功能活性的不同方法的重要评估。

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摘要

Antibodies are thought to be the primary immune effectors in the defense against erythrocytic stage Plasmodium falciparum. Thus, malaria vaccines directed to blood stages of infection are evaluated based on their ability to induce antibodies with anti-parasite activity. Such antibodies may have different effector functions (e.g., inhibition of invasion or inhibition of parasite growth/development) depending on the target antigen. We evaluated four methods with regards to their ability to differentiate between invasion and/or growth inhibitory activities of antibodies specific for two distinct blood stage antigens: AMA1 and MSP1(42). We conclude that antibodies induced by these vaccine candidates have different modes of action that vary not only by the antigen, but also by the strain of parasite being tested. Analysis based on parasitemia and viability was essential for defining the full range of anti-parasite activities in immune sera.
机译：抗体被认为是防御红细胞阶段恶性疟原虫的主要免疫效应物。因此，基于其诱导具有抗寄生虫活性的抗体的能力来评估针对感染的血液阶段的疟疾疫苗。取决于靶抗原，此类抗体可具有不同的效应子功能（例如，抑制入侵或抑制寄生虫生长/发育）。我们评估了四种方法，以区分对两种不同的血液阶段抗原（AMA1和MSP1）具有特异性的抗体的侵袭和/或生长抑制活性（42）。我们得出的结论是，由这些候选疫苗诱导的抗体具有不同的作用方式，这些作用方式不仅随抗原变化，而且随所测试的寄生虫菌株而变化。基于寄生虫血症和生存力的分析对于定义免疫血清中所有抗寄生虫活性至关重要。

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