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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Malaria chemoprophylaxis: what do the travelers choose, and how does pretravel consultation influence their final decision.
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Malaria chemoprophylaxis: what do the travelers choose, and how does pretravel consultation influence their final decision.

机译：疟疾的化学预防：旅行者选择什么，旅行前咨询如何影响他们的最终决定。

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摘要

Three different drugs (mefloquine, atovaquone/proguanil, doxycycline) are recommended for malaria chemoprophylaxis, each with approximately the same efficacy but various adverse event profiles, regimens, and prices. We investigated which medication the travelers would have chosen on the basis of written evidence-based information and the impact that pretravel consultation had on their decision. A prospective study was performed in a travel clinic and private practice, and 1073 travelers were included; 45% chose mefloquine (Lariam or Mephaquine), 21% atovaquone/proguanil (Malarone), 18% doxycycline (Supracycline), 5% "no prophylaxis," and 11% "do not know." Lariam was principally chosen because of prior experience (38%), Mephaquine because of low price (34%), and doxycycline and Malarone because of the profile of adverse events (55% and 43%, respectively). Based on objective written information, travelers most frequently chose mefloquine for chemoprophylaxis. This suggests that evidence-based information weighs more heavily than negative publicity. Taking into account the perspective of the user should improve appropriateness of the pretravel advice.
机译：推荐使用三种不同的药物（甲氟喹，阿托伐醌/鸟嘌呤，多西环素）进行疟疾的化学预防，每种药物的疗效大致相同，但不良事件概况，治疗方案和价格各不相同。我们根据书面的循证信息以及旅行前咨询对他们的决定产生的影响，研究了旅行者会选择哪种药物。在旅行诊所和私人诊所进行了一项前瞻性研究，其中包括1073名旅行者; 45％的人选择了甲氟喹（Lariam或Mephaquine），21％的阿托伐醌/异丙胍（马拉隆），18％的强力霉素（超环素），5％的“无预防作用”和11％的“不知道”。选择拉里亚姆的原因是以前的经验（38％），选择甲氧喹的原因是价格低（34％），而多西环素和马拉兰是因为不良事件的发生率（分别为55％和43％）。根据客观的书面信息，旅行者最经常选择甲氟喹进行化学预防。这表明基于证据的信息比负面宣传更为重要。考虑到用户的观点，应提高旅行前建议的适当性。

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