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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Enhanced malaria parasite transmission from helminth co-infected mice.
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Enhanced malaria parasite transmission from helminth co-infected mice.

机译：从蠕虫感染的小鼠中增强的疟原虫传播。

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摘要

Helminth infections are prevalent in malaria-endemic areas, yet the potential for helminths to alter malaria transmission has not been closely examined. We used the Echinostoma caproni-Plasmodium yoelii murine model of co-infection to assess the impact of helminth co-infection on malaria transmission. In four replicate experiments, Anopheles stephensi mosquitoes exposed to co-infected mice five days post-malaria infection had a higher rate of infectivity (80.1%, n = 241) than those exposed to malaria only-infected mice (72.0%, n = 232, P = 0.039). Intensity of malaria parasite transmission was also greater, with approximately two-fold more oocysts (geometric mean = 19.2 versus 10.5, P = 0.004) and an increase in sporozoite burden observed in mosquitoes exposed to co-infected mice. Malaria parasite prevalence and anemia were similar between co-infected and malaria only-infected mice, which suggested that enhanced malaria parasite transmission was due to helminth-induced modulation of host responses.
机译：蠕虫感染在疟疾流行地区很普遍，但尚未仔细研究蠕虫改变疟疾传播的潜力。我们使用共感染的棘孢棘皮虫-约氏疟原虫鼠模型来评估蠕虫共感染对疟疾传播的影响。在四个重复实验中，疟疾感染后五天暴露于共同感染小鼠的Stephensi蚊子的感染率（80.1％，n = 241）高于仅感染疟疾感染的小鼠（72.0％，n = 232） ，P = 0.039）。疟疾寄生虫传播的强度也更大，卵囊大约增加了两倍（几何平均值= 19.2比10.5，P = 0.004），并且在暴露于共感染小鼠的蚊子中子孢子的负担增加了。合并感染和仅感染疟疾的小鼠之间的疟原虫流行和贫血相似，这表明疟原虫传播的增强是由于蠕虫诱导的宿主反应调节。

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