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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >The immune response to toxocariasis does not modify susceptibility to Mycobacterium tuberculosis infection in BALB/c mice.
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The immune response to toxocariasis does not modify susceptibility to Mycobacterium tuberculosis infection in BALB/c mice.

机译：对弓形虫病的免疫反应不会改变BALB / c小鼠对结核分枝杆菌感染的敏感性。

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摘要

Mycobacterium tuberculosis and helminth infections coincide geographically and are classically described as TH1 and TH2 pathologies. There is much interest in exploring how concurrent worm infections might alter immune responses to mycobacterial infection. To explore this issue, mice were infected with Toxocara canis and co-infected with M. tuberculosis. Mice infected with M. tuberculosis had high numbers of neutrophils and mononuclear cells within the alveolar spaces, with increased parenchymal interferon (IFN)-gamma levels. However, in Toxocara-infected mice we detected increased eosinophil numbers in bronchoalveolar lavage fluid (BALF) and increased parenchymal levels of interleukin (IL)-5. In co-infected mice the BALF demonstrated enhanced eosinophil influx with decreased neutrophil and mononuclear cell accumulation. However, co-infected mice had similar mycobacterial proliferation in their lungs accompanied by similar histopathological changes and similar cytokineitric oxide production compared with Mycobacterium-only-infected mice. Our results suggest that T. canis infection does not necessarily lead to increased susceptibility to pulmonary tuberculosis.
机译：结核分枝杆菌和蠕虫感染在地理上是重合的，并且通常被描述为TH1和TH2病理。探索并发蠕虫感染如何改变对分枝杆菌感染的免疫反应引起了很多兴趣。为了探讨这个问题，将小鼠感染犬弓形虫并与结核分枝杆菌共同感染。感染结核分枝杆菌的小鼠的肺泡腔内嗜中性粒细胞和单核细胞数量很高，实质干扰素（IFN）-γ水平升高。但是，在弓形虫感染的小鼠中，我们检测到支气管肺泡灌洗液（BALF）中的嗜酸性粒细胞数量增加，而白细胞介素（IL）-5的实质水平升高。在合并感染的小鼠中，BALF表现出嗜酸性粒细胞流入增强，嗜中性粒细胞减少和单核细胞积聚。但是，与仅感染分枝杆菌的小鼠相比，合并感染的小鼠的肺部分支杆菌具有相似的增殖，同时具有相似的组织病理学变化和类似的细胞因子/一氧化氮生成。我们的结果表明，犬圆弧菌感染不一定导致对肺结核的易感性增加。

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