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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Antiplasmodial interactions between artemisinin and triclosan or ketoconazole combinations against blood stages of Plasmodium falciparum in vitro.
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Antiplasmodial interactions between artemisinin and triclosan or ketoconazole combinations against blood stages of Plasmodium falciparum in vitro.

机译：青蒿素与三氯生或酮康唑组合之间的抗血浆相互作用对恶性疟原虫的血液阶段具有体外作用。

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摘要

Emergence of drug-resistant Plasmodium falciparum strains to conventional first-line antimalarial drugs has compelled many countries to reorient their drug policies to adopt artemisinin-based combination therapies (ACTs) for treatment of uncomplicated malaria. This has increased the demand of artemisinin, already a scarce commodity. Synthesis of artemisinin is not yet commercially viable. Extensive use of available ACTs will invariably lead to emergence of resistance to these combinations. Thus, there is need to search for new artemisinin-based synthetic, inexpensive, synergistic combinations to reduce dependence on artemisinin. In vitro cultures of P. falciparum provide an appropriate system for identification of such new combinations. We evaluated interactions of artemisinin with triclosan or ketoconazole against blood stages of P. falciparum by a fixed-ratio isobologram method. Artemisinin shows mild synergistic interaction with triclosan and slight to marked antagonism with ketoconazole in vitro. These antiplasmodial interactions, however, require confirmation using in vivo model systems.
机译：耐药性恶性疟原虫菌株向常规一线抗疟药的涌现迫使许多国家重新调整其药物政策，以采用基于青蒿素的联合疗法（ACT）来治疗单纯性疟疾。这增加了青蒿素的需求，青蒿素已经是一种稀缺的商品。青蒿素的合成尚无商业可行性。大量使用可用的ACT总是会导致对这些组合产生抗药性。因此，需要寻找新的基于青蒿素的合成，廉价，协同组合以减少对青蒿素的依赖性。恶性疟原虫的体外培养提供了鉴定这种新组合的合适系统。我们通过固定比率等效线图法评估了青蒿素与三氯生或酮康唑对恶性疟原虫血液阶段的相互作用。青蒿素在体外显示出与三氯生的温和协同作用，与酮康唑的拮抗作用微弱至明显。但是，这些抗血浆相互作用需要使用体内模型系统进行确认。

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