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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Identification of aerobic gut bacteria from the kala azar vector, Phlebotomus argentipes: a platform for potential paratransgenic manipulation of sand flies.
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Identification of aerobic gut bacteria from the kala azar vector, Phlebotomus argentipes: a platform for potential paratransgenic manipulation of sand flies.

机译：从黑热病媒介中检出有氧肠道细菌，即白僵菌：一个潜在的转基因操纵沙蝇的平台。

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摘要

Visceral leishmaniasis is an understudied parasitic disease responsible for significant global morbidity and mortality. We are presently investigating a method of disease prevention termed paratransgenesis. In this approach, symbiotic or commensal bacteria are transformed to produce anti-Leishmania molecules. The transformed bacteria are delivered back to sand flies to inactivate the parasite within the vector itself. In this study, we identified 28 distinct gut microorganisms from Phlebotomus argentipes trapped from four visceral leishmaniasis-endemic sites in India. A significant percent of Staphylococcus spp., environmental bacteria, and Enterobacteriaceae were identified. Two non-pathogenic organisms, Bacillus megaterium and Brevibacterium linens, were also isolated. Both organisms are also used extensively in industry. Our results indicate that B. megaterium and B. linens are possible candidates for use in a model of paratransgenesis to prevent transmission of Leishmania.
机译：内脏利什曼病是一种未被充分研究的寄生虫病，可导致明显的全球发病率和死亡率。我们目前正在研究一种称为副转基因的疾病预防方法。在这种方法中，共生或共生细菌被转化产生抗利什曼原虫分子。转化的细菌被送回沙蝇以灭活载体本身内的寄生虫。在这项研究中，我们从印度的四个内脏利什曼病流行部位捕获了来自阿根廷细支杆菌的28种不同的肠道微生物。确定了很大比例的葡萄球菌属，环境细菌和肠杆菌科。还分离出了两种非致病性生物，即巨大芽孢杆菌和短杆菌。两种生物还广泛用于工业中。我们的结果表明，巨大芽孢杆菌和亚麻杆菌可能是用于准转基因模型以防止利什曼原虫传播的候选对象。

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