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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Short Report: Prevalence of Antimalarial Drug Resistance Mutations in Plasmodium vivax and P. falciparum from a Malaria-Endemic Area of Pakistan
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Short Report: Prevalence of Antimalarial Drug Resistance Mutations in Plasmodium vivax and P. falciparum from a Malaria-Endemic Area of Pakistan

机译：简短报告：巴基斯坦疟疾流行区间日疟原虫和恶性疟原虫中抗疟药耐药突变的流行

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摘要

To study drug resistance in Bannu district, a malaria-endemic area in Pakistan, molecular-based analyses were undertaken. In Plasmodium vivax, antifolate resistance mutations were detected in pvdhfr gene codons 57,58, and 117, with a 117N mutation frequency of 93.5%. All P. falciparum isolates exhibited double 59R + 108N mutations inpfdhfr, whereas the triple mutant 59R + 108N + 437G haplotype was found in 31.8% isolates. Furthermore, all (100%) P. falciparum isolates exhibited the key chloroquine resistance mutation, pfcrt 76T, which is also associated with resistance to amodiaquine. Additionally,pfmdrl 86Y and D1042Y mutations were, respectively, detected in 32% and 9% isolates. These results indicate an emerging multi-drug resistance problem in P. vivax and P. falciparum malaria parasites in Pakistan.
机译：为了研究巴基斯坦疟疾流行区Bannu地区的耐药性，进行了基于分子的分析。在间日疟原虫中，在pvdhfr基因密码子57,58和117中检测到抗叶酸抗性突变，其117N突变频率为93.5％。所有恶性疟原虫分离株在pfdffr中均显示出双59R + 108N突变，而在31.8％分离株中发现了三突变体59R + 108N + 437G单倍型。此外，所有（100％）恶性疟原虫的分离株均显示出关键的氯喹抗性突变pfcrt 76T，该突变也与对阿莫地喹的抗性有关。另外，分别在32％和9％的分离物中检测到pfmdrl 86Y和D1042Y突变。这些结果表明巴基斯坦间日疟原虫和恶性疟原虫疟疾寄生虫中出现了新的多药耐药性问题。

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