...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Genetic consequences of mass human chemotherapy for Schistosoma mansoni: population structure pre- and post-praziquantel treatment in Tanzania.
【24h】

Genetic consequences of mass human chemotherapy for Schistosoma mansoni: population structure pre- and post-praziquantel treatment in Tanzania.

机译：大规模人类化学疗法治疗曼氏血吸虫的遗传后果：坦桑尼亚吡喹酮治疗前后的种群结构。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recent shifts in global health policy have led to the implementation of mass drug administration (MDA) for neglected tropical diseases. Here we show how population genetic analyses can provide vital insights into the impact of such MDA on endemic parasite populations. We show that even a single round of MDA produced a genetic bottleneck with reductions in a range of measures of genetic diversity of Schistosoma mansoni. Phylogenetic analyses and indices of population differentiation indicated that schistosomes collected in the same schools in different years were more dissimilar than those from different schools collected within either of the study's 2 years, in addition to distinguishing re-infection from non-clearance (that might indicate putatively resistant parasites) from within those children infected at both baseline and follow-up. Such unique results illustrate the importance of genetic monitoring and examination of long lived multi-cellular parasites such as these under novel or increased chemotherapeutic selective pressures.
机译：全球卫生政策的最新变化已导致对被忽视的热带病实施大规模药物管理（MDA）。在这里，我们展示了人口遗传学分析如何可以提供关于此类MDA对地方性寄生虫种群影响的重要见解。我们显示，即使是一轮MDA产生的遗传瓶颈，曼氏血吸虫的遗传多样性范围也有所减少。系统发育分析和种群分化指数表明，在同一年份不同学校收集的血吸虫病比该研究的任一个两年内在不同学校收集的血吸虫病更为不同（除了区分再感染与未清除）（这可能表明在基线和随访期间感染的那些儿童中的推定抗性寄生虫）。这样独特的结果说明了在新的或增加的化学治疗选择压力下，对长寿命的多细胞寄生虫（例如这些）进行遗传监测和检查的重要性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号