Decreased lactic acidosis and anemia after transfusion of o-raffinose cross-linked and polymerized hemoglobin in severe murine malaria.

Freilich D; Branda R; Hacker M; Leach L; Barry B; Ferris S; Hebert J

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Decreased lactic acidosis and anemia after transfusion of o-raffinose cross-linked and polymerized hemoglobin in severe murine malaria.

机译：在严重的鼠类疟疾中输注o-棉子糖交联和聚合的血红蛋白后，乳酸酸中毒和贫血减少。

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摘要

Severe anemia is a major cause of death in falciparum malaria. Blood transfusion increases survival in humans and in animal models of this disease. Because of logistic constraints and viral contamination of the blood supply, transfusions are frequently not practical in endemic regions. Modified hemoglobin is an effective O2 carrier in hemorrhagic shock. It is free of infectious contamination, may not require refrigeration, and because of its nitric oxide scavenging and small size, may have pharmacologic benefits in malaria. The effects of transfusions of modified hemoglobin in rats with high-grade parasitemia were evaluated. Modified hemoglobin decreased lactic acidosis and corrected anemia as well as transfusions with red blood cells; these findings may correlate with improved survival and suggest a possible proerythropoietic effect. Further study of this novel therapy is warranted.

机译：严重贫血是恶性疟疾死亡的主要原因。输血增加了人类和该疾病动物模型的存活率。由于后勤方面的限制和血液供应的病毒污染，在流行地区输血常常是不实际的。修饰的血红蛋白是失血性休克中有效的O2载体。它没有传染性污染，可能不需要冷藏，并且由于其清除一氧化氮且体积小，可能在疟疾中具有药理作用。评估了改良血红蛋白输注对高度寄生虫病大鼠的影响。改良的血红蛋白可减少乳酸性酸中毒并纠正贫血以及输注红细胞;这些发现可能与生存改善有关，并提示可能的促红细胞生成作用。有必要对该新疗法进行进一步研究。

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来源
《The American Journal of Tropical Medicine and Hygiene》 |1999年第2期|共7页
作者
Freilich D; Branda R; Hacker M; Leach L; Barry B; Ferris S; Hebert J;
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正文语种 eng
中图分类地方病学;
关键词
Acidosis; Lactic; Anemia; Hemoglobins; Malaria; Falciparum; Raffinose; hemolink; 酸中毒; 乳酸性; 贫血; 血红蛋白类; 疟疾; 恶性; 棉子糖;

机译：Acidosis;Lactic;Anemia;Hemoglobins;Malaria;Falciparum;Raffinose;hemolink;酸中毒;乳酸性;贫血;血红蛋白类;疟疾;恶性;棉子糖;

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1. Decreased lactic acidosis and anemia after transfusion of o-raffinose cross-linked and polymerized hemoglobin in severe murine malaria. [J] . Freilich D, Branda R, Hacker M, The American Journal of Tropical Medicine and Hygiene . 1999,第2期

机译：在严重的鼠类疟疾中输注o-棉子糖交联和聚合的血红蛋白后，乳酸酸中毒和贫血减少。
2. Metabolic acidosis and other determinants of hemoglobin-oxygen dissociation in severe childhood Plasmodium falciparum malaria. [J] . Sasi P, Burns SP, Waruiru C, The American Journal of Tropical Medicine and Hygiene . 2007,第2期

机译：严重儿童期恶性疟原虫疟疾的代谢性酸中毒和血红蛋白-氧解离的其他决定因素。
3. Safety and efficacy of o-raffinose cross-linked human hemoglobin (Hemolink) in cardiac surgery. [J] . Cheng DC Canadian journal of anesthesia: Journal canadien d'anesthesie . 2001,第4Suppla期

机译：o-棉子糖交联的人类血红蛋白（Hemolink）在心脏手术中的安全性和有效性。
4. Characterization of hemoglobin C and other variant hemoglobin erythrocytes and their protective mechanism against severe malaria. [D] . Brittain, Nathaniel. 2006

机译：血红蛋白C和其他变体血红蛋白红细胞的特征及其对严重疟疾的保护机制。
5. Differing Causes of Lactic Acidosis and Deep Breathing in Cerebral Malaria and Severe Malarial Anemia May Explain Differences in Acidosis-Related Mortality [O] . Nathan R. Brand, Robert O. Opoka, Karen E. S. Hamre, -1

机译：大脑性疟疾和严重疟疾中乳酸性酸中毒和深呼吸的不同原因可能解释了酸中毒相关死亡率的差异
6. Differing Causes of Lactic Acidosis and Deep Breathing in Cerebral Malaria and Severe Malarial Anemia May Explain Differences in Acidosis-Related Mortality. [O] . Nathan R Brand, Robert O Opoka, Karen E S Hamre, 2016

机译：脑疟疾和严重疟疾贫血的乳酸酸中毒和深呼吸的差异原因可能解释酸中毒相关死亡率的差异。

Decreased lactic acidosis and anemia after transfusion of o-raffinose cross-linked and polymerized hemoglobin in severe murine malaria.

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