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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Visceral Leishmaniasis Caused by Leishmania infantum in Salta, Argentina: Possible Reservoirs and Vectors
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Visceral Leishmaniasis Caused by Leishmania infantum in Salta, Argentina: Possible Reservoirs and Vectors

机译：由阿根廷萨尔塔省婴儿利什曼原虫引起的内脏利什曼病：可能的水库和载体

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摘要

Cases of human visceral leishmaniasis (HVL) were not recorded until recently in the Chaco region of northwestern Argentina. Dogs were surveyed at the sites of infection of two HVL index cases in the Chaco region of Salta province. Canine cases (CanL) were diagnosed by two parasitological methods, two molecular methods targeting mini- and maxicircle DNA, and immunochromatographic dipstick. Among 77 dogs studied, 10 (13%) were found infected with Leishmania spp. In seven dogs and two humans, the infecting species was typed as Leishmania (Leishmania) infantum. The same genotype was detected in the human and two of the CanL. Although several diagnostic methods displayed weak or moderate agreement, the concordance values for serology versus maxicircle PCR were very good (Kappa index = 0.84). Sandflies captured in the area were identified as Lutzomyia migonei and Lu. cortelezziau. sallesi (cortelezzii complex). The focal appearance of leishirnaniasis in dogs and humans in a sylvatic region and its relatively low prevalence of infection suggests that L. (L.) infantum transmission to dogs and humans may, in this region, stem from sylvatic reservoirs.
机译：直到最近在阿根廷西北部的查科地区才记录到人类内脏利什曼病（HVL）。在萨尔塔省查科地区的两个HVL指数病例的感染地点对狗进行了调查。犬病（CanL）是通过两种寄生虫学方法，针对小和最大圆环DNA的两种分子方法以及免疫色谱试纸诊断的。在研究的77只狗中，有10只（13％）被发现感染了利什曼原虫。在七只狗和两个人类中，感染物种的类型为利什曼原虫（Leishmania）infantum。在人类和两个CanL中检测到相同的基因型。尽管几种诊断方法显示出弱或中度一致性，但血清学检查与最大环PCR的一致性非常好（Kappa指数= 0.84）。在该地区捕获的沙蝇被确定为米色Lutzomyia migonei和Lu。 Cortelezziau。 sallesi（cortelezzii复合体）。 sylvatic地区的狗和人中的利什曼尼亚病的病灶外观及其相对较低的感染率表明，在该地区，L。（L.）婴幼儿向狗和人的传播可能源自sylvatic水库。

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