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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >The epidemiology of Plasmodium falciparum malaria in two Cameroonian villages: Simbok and Etoa.
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The epidemiology of Plasmodium falciparum malaria in two Cameroonian villages: Simbok and Etoa.

机译:喀麦隆两个村庄:Simbok和Etoa的恶性疟原虫疟疾流行病学。

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摘要

In support of ongoing immunologic studies on immunity to Plasmodium falciparum, demographic, entomologic, parasitologic, and clinical studies were conducted in two Cameroonian villages located 3 km apart. Simbok (population = 907) has pools of water present year round that provide breeding sites for Anopheles gambiae, whereas Etoa (population = 485) has swampy areas that dry up annually in which A. funestus breed. Results showed that individuals in Simbok receive an estimated 1.9 and 1.2 infectious bites per night in the wet and dry season, respectively, whereas individuals in Etoa receive 2.4 and 0.4 infectious bites per night, respectively. Although transmission patterns differ, the rate of acquisition of immunity to malaria appears to be similar in both villages. A prevalence of 50-75% was found in children < 10 years old, variable levels in children 11-15 years old, and 31% in adults. Thus, as reported in other parts of Africa, individuals exposed to continuous transmission of P. falciparum slowly acquired significant, but not complete, immunity.
机译:为了支持正在进行的关于恶性疟原虫免疫的免疫学研究,在相距3公里的两个喀麦隆村庄进行了人口统计学,昆虫学,寄生虫学和临床研究。 Simbok(人口= 907)全年都有水塘,为冈比亚按蚊提供繁殖场所,而Etoa(人口= 485)的沼泽地每年枯竭,其中有A. funestus繁殖。结果显示,辛博克地区的人在潮湿和干旱的季节每晚分别受到感染和叮咬的次数分别为1.9和1.2,而埃托瓦州的个人分别受到每晚2.4和0.4的感染力。尽管传播方式不同,但在两个村庄中获得抗疟疾免疫力的比率似乎相似。在10岁以下的儿童中患病率为50-75%,在11-15岁的儿童中患病水平不同,成人为31%。因此,正如非洲其他地区所报道的那样,暴露于恶性疟原虫持续传播的个体缓慢获得了重要但并非完全的免疫力。

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