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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Short report: therapeutic efficacy of chloroquine combined with primaquine against Plasmodium falciparum in northeastern Papua, Indonesia.
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Short report: therapeutic efficacy of chloroquine combined with primaquine against Plasmodium falciparum in northeastern Papua, Indonesia.

机译：简短报告：氯喹联合伯氨喹对印度尼西亚巴布亚东北部恶性疟原虫的治疗效果。

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摘要

Chloroquine combined with primaquine was evaluated for therapy of uncomplicated malaria caused by Plasmodium falciparum in nonimmune Javanese migrants to northeastern Papua, Indonesia. Subjects were randomized to treatment with standard chloroquine therapy (25 mg/kg in 3 doses over the course of 48 hours) with 30 mg primaquine administered daily for 28 days (n = 25) or a placebo of primaquine (n = 28). The 14-day cumulative incidence of therapeutic failure was 56% with primaquine and 79% with placebo (odds ratio [OR], 0.35; 95% confidence interval [CI], 0.1-1.3; P = 0.08). Primaquine administered daily created a marginally significant improvement in therapeutic efficacy at day 14, but not at day 7 (20% versus 36%; OR, 0.2; 95% CI, 0.1-1.8; P = 0.2) or day 28 (82% versus 93%; OR, 0.31; 95% Cl, 0.04-2.1; P = 0.23). This report corroborates studies suggesting that therapeutic doses of primaquine exert no discernible effect on parasitemia by P. falciparum.
机译：评估了氯喹联合伯氨喹对非免疫性爪哇人迁往印度尼西亚东北巴布亚的恶性疟原虫引起的单纯性疟疾的治疗效果。受试者随机接受标准氯喹治疗（在48小时内分3剂以25毫克/千克的剂量），每天服用30毫克伯氨喹，持续28天（n = 25），或安慰剂伯氨喹（n = 28）。伯氨喹治疗14天的治疗失败累积发生率为56％，安慰剂为79％（几率[OR]为0.35; 95％置信区间[CI]为0.1-1.3; P = 0.08）。每天给药的Primaquine在第14天或第7天（20％比36％; OR，0.2; 95％CI，0.1-1.8; P = 0.2）或第28天（约82％vs. 93％; OR，0.31; 95％Cl，0.04-2.1; P = 0.23）。该报告证实了研究，表明治疗剂量的伯氨喹对恶性疟原虫的寄生虫病没有明显的作用。

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