...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Randomized comparison of low-dose versus standard-dose praziquantel therapy in treatment of urinary tract morbidity due to Schistosoma haema tobium infection.
【24h】

Randomized comparison of low-dose versus standard-dose praziquantel therapy in treatment of urinary tract morbidity due to Schistosoma haema tobium infection.

机译：小剂量吡喹酮治疗与标准剂量吡喹酮治疗血吸虫血b感染所致尿路发病的随机比较。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

At present, anthelmintic therapy with praziquantel at a dose of 40 mg/kg of body weight is the recommended treatment for control of urinary tract morbidity caused by Schistosoma haematobium. Although this standard regimen is effective, drug cost may represent a significant barrier to implementation of large-scale schistosomiasis control programs in developing areas. Previous comparison trials have established that low-dose (20-30 mg/kg) praziquantel regimens can effectively suppress the intensity of S. haematobium infection in endemic settings. However, the efficacy of these low-dose regimens in controlling infection-related morbidity has not been determined in a randomized field trial. The present random allocation study examined the relative efficacy of a 20 mg/kg dose versus a 40 mg/kg dose of praziquantel in control of hematuria and bladder and renal abnormalities associated with S. haematobium infection in an endemic area of Coast Province, Kenya. After a nine-month observation period, the results indicated an advantage to the standard 40 mg/kg praziquantel dose in terms of reduction of infection prevalence and hematuria after therapy (P < 0.01 and P < 0.005, respectively). However, the two treatment groups were equally effective in reducing structural urinary tract morbidity detected on ultrasound examination. We conclude that in certain settings, a 20 mg/kg dose of praziquantel may be sufficient in providing control of morbidity due to urinary schistosomiasis in population-based treatment programs.
机译：目前，推荐使用吡喹酮以40 mg / kg体重的剂量进行驱虫治疗，以控制由血吸虫血红蛋白引起的尿路发病。尽管该标准方案是有效的，但药品成本可能代表着在发展中国家实施大规模血吸虫病控制计划的重大障碍。先前的比较试验已经确定，低剂量（20-30 mg / kg）吡喹酮方案可以在地方性流行环境中有效抑制沙门氏菌感染的强度。但是，这些低剂量方案在控制感染相关发病率中的功效尚未在一项随机现场试验中确定。目前的随机分配研究检查了吡喹酮20 mg / kg剂量与40 mg / kg剂量的吡喹酮在控制与肯尼亚海岸省流行地区血友病链球菌感染相关的血尿和膀胱及肾脏异常方面的相对疗效。经过9个月的观察期后，结果表明，在减少治疗后的感染率和血尿方面，标准的40 mg / kg吡喹酮剂量具有优势（分别为P <0.01和P <0.005）。但是，两个治疗组在减少超声检查发现的结构性尿路发病率方面均有效。我们得出的结论是，在某些人群中，以人群为基础的治疗方案中，吡喹酮20 mg / kg的剂量可能足以控制由于尿血吸虫病引起的发病。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号