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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Cytoadherence characteristics of Plasmodium falciparum isolates in Thailand using an in vitro human lung endothelial cells model.
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Cytoadherence characteristics of Plasmodium falciparum isolates in Thailand using an in vitro human lung endothelial cells model.

机译：使用体外人肺内皮细胞模型在泰国恶性疟原虫分离株的细胞粘附特性。

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摘要

Using an in vitro model of human lung endothelial cells, we studied different characteristics of Plasmodium falciparum isolates as potential factors for malaria severity in 2 Thai patient groups: 27 with complicated malaria and 42 with uncomplicated malaria. In regard to binding properties, no association existed between cytoadherence and rosette phenotypes (P = 0.1) and hypothrombocytemia increased the cytoadherence level (P = 0.007). Cytoadherence was significantly associated with malaria severity (P = 0.05) in contrast to rosette formation (P = 0.9). Intercellular adhesion molecule-1 and chondroitin-4-sulfate were major receptors of cytoadherence in those with complicated malaria compared with those with uncomplicated malaria (P < 10(-4)). Chondroitin-4-sulfate could act as a putative receptor for malaria complications in non-pregnant women. CD36 was the main receptor in patients with uncomplicated malaria (P < 10(-3)). Vascular cell adhesion molecule-1 and E-selectin played a minor role in 2 groups (P = 0.6). Qinghaosu derivatives were more efficient than other antimalarial drugs, but a positive correlation was observed between the 50% inhibitory concentrations of halofantrine and quinine and the number of adhesive parasitized red blood cells, suggesting their influence on cytoadherence.
机译：使用人肺内皮细胞的体外模型，我们研究了恶性疟原虫分离株的不同特征，将其作为2个泰国患者组中疟疾严重程度的潜在因素：27例复杂的疟疾和42例简单的疟疾。关于结合特性，细胞粘附性与玫瑰花结型之间不存在关联（P = 0.1），而血小板减少症会增加细胞粘附性水平（P = 0.007）。与玫瑰花结形成（P = 0.9）相比，细胞粘附与疟疾严重程度显着相关（P = 0.05）。与不伴有疟疾的人相比，伴有疟疾的人的细胞间粘附分子-1和软骨素-4-硫酸盐是细胞粘附的主要受体（P <10（-4））。硫酸软骨素4可以作为非妊娠妇女疟疾并发症的假定受体。 CD36是单纯性疟疾患者的主要受体（P <10（-3））。血管细胞粘附分子-1和E-选择素在两组中的作用较小（P = 0.6）。 Qinghaosu衍生物比其他抗疟药更有效，但在50％的抑制浓度的氟替林和奎宁与粘附的寄生红细胞数量之间发现正相关，表明它们对细胞粘附具有影响。

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