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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Hepatitis C in Peru: risk factors for infection, potential iatrogenic transmission, and genotype distribution.
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Hepatitis C in Peru: risk factors for infection, potential iatrogenic transmission, and genotype distribution.

机译：秘鲁的丙型肝炎：感染，潜在医源性传播和基因型分布的危险因素。

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摘要

A large seroepidemiologic and genotyping study of hepatitis C virus (HCV) was conducted in Lima, Peru, during the periods of 1986 to 1993 (cohort A) and 1994 (cohort B). Anti-HCV seroprevalence rates were 15.6% (216 of 1,389) and 11.7% (168 of 1,438), respectively. Low rates were seen among volunteer blood donors (1.1% and 0.8%). Anti-HCV rates were much higher among patients undergoing hemodialysis (43.7% and 59.3%), hemophiliacs (60.0% and 83.3%), in those more than 39 years old (18.2% and 26.0%), in females (25.0% and 27.4%), and in less-educated persons (16.9%). Age- and gender-adjusted risk factors in cohort B included blood transfusion history (adjusted odds ratio [AOR] = 29.8), prior organ transplantation (AOR = 9.1) or a history of hepatitis (AOR = 4.9), previous hospitalization (AOR = 3.7), a history of intravenous drug use (AOR = 3.5), prior major surgery (AOR = 2.6), a history of acupuncture (AOR = 2.1), previous dental procedures (AOR = 1.2), and prior medical injections (AOR = 1.04). The most prevalent HCV genotype was type 1 (86%), followed by type 3 (10%) and type 2 (2%). Transmission through unsafe injection-related and medical/dental procedures appears to play an important role in HCV infection among Peruvians.
机译：在1986年至1993年（A组）和1994年（B组）期间，在秘鲁利马进行了丙型肝炎病毒（HCV）的大型流行病学和基因分型研究。抗HCV血清阳性率分别为15.6％（1,389中的216）和11.7％（1,438中的168）。自愿献血者的比率很低（1.1％和0.8％）。接受血液透析的患者（43.7％和59.3％），血友病患者（60.0％和83.3％），39岁以上的患者（18.2％和26.0％），女性（25.0％和27.4）的抗HCV率要高得多％），以及受教育程度较低的人（16.9％）。队列B中按年龄和性别调整的危险因素包括输血史（调整后的优势比[AOR] = 29.8），先前的器官移植（AOR = 9.1）或肝炎病史（AOR = 4.9），先前的住院治疗（AOR = 3.7），静脉药物使用史（AOR = 3.5），先前的大手术（AOR = 2.6），针灸史（AOR = 2.1），先前的牙科手术（AOR = 1.2）和先前的药物注射（AOR = 1.04）。 HCV最普遍的基因型是1型（86％），其次是3型（10％）和2型（2％）。通过不安全的注射相关和医学/牙科程序传播的病毒似乎在秘鲁人的HCV感染中起重要作用。

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