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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Epidemic of hepatitis E in a military unit in Abbotrabad, Pakistan.
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Epidemic of hepatitis E in a military unit in Abbotrabad, Pakistan.

机译：巴基斯坦阿伯塔巴德一个军事单位的戊型肝炎流行。

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摘要

An outbreak of hepatitis caused by hepatitis E virus (HEV) in Abbottabad, Pakistan was traced to fecal contamination of a water system. Of 109 men hospitalized with hepatitis, 104 (95%) had serologic evidence of acute hepatitis E (IgM antibody to HEV [anti-HEV]), three (3%) probably had acute hepatitis E (high titers of IgG anti-HEV without IgM), and two had acute hepatitis A. Among a subset of 44 men with acute hepatitis E from whom three serum specimens were obtained over a four-month period, the anti-HEV IgG geometric mean titers (GMTs) decreased from 1,519 during the outbreak to 657 at four months. The IgM anti-HEV was detected in 40 (91%) of 44 sera obtained at admission (GMT = 533 during acute disease), but in only six (14%) four months later. The prevalence of anti-HEV in this population before the outbreak was estimated to be 30%. The presence of IgG anti-HEV appeared to protect against clinical hepatitis or development of serologic evidence of new infection with HEV. This is the second major epidemic of hepatitis E in the Pakistani military confirmed by an anti-HEV enzyme-linked immunosorbent assay (ELISA). Evidence that pre-existing antibody as measured by this ELISA protects against disease is important for assessment of vaccine development.
机译：在巴基斯坦的阿伯塔巴德爆发了由戊型肝炎病毒（HEV）引起的肝炎暴发，其原因是水系统的粪便受到污染。在109名肝炎住院患者中，有104名（95％）的血清学证据为急性戊型肝炎（HEV的IgM抗体[抗-HEV]），三名（3％）可能患有急性戊型肝炎（高滴度的IgG抗-HEV抗体IgM），其中2人患有急性A型肝炎。在44例急性E型肝炎患者中，在四个月内获得了3份血清标本，其抗HEV IgG几何平均滴度（GMT）从1,519降低了。在四个月内爆发到657。在入院时获得的44份血清中有40份（91％）检测到IgM抗HEV（急性疾病期间GMT = 533），但四个月后仅检测到6份（14％）。爆发前该人群中抗HEV的患病率估计为30％。 IgG抗HEV的存在似乎可以预防临床肝炎或新感染HEV的血清学证据的发展。通过抗HEV酶联免疫吸附测定（ELISA）证实，这是巴基斯坦军方第二次戊型肝炎主要流行病。通过此ELISA测定的预先存在的抗体可以预防疾病的证据对于评估疫苗开发非常重要。

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