...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Identification and characterization of Sarcoptes scabiei and Dermatophagoides pteronyssinus glutathione S-transferases: implication as a potential major allergen in crusted scabies.
【24h】

Identification and characterization of Sarcoptes scabiei and Dermatophagoides pteronyssinus glutathione S-transferases: implication as a potential major allergen in crusted scabies.

机译：鉴定和表征Sarcoptes scabiei和Dermatophagoides pteronyssinus谷胱甘肽S-转移酶：作为结s中潜在的主要过敏原。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The astigmatid mite Sarcoptes scabiei is the causative agent of scabies, a highly infectious parasitic disease of the skin. Although the mite causes marked hypersensitivity reactions, particularly in crusted (severe) scabies, little is known about the specific scabies mite molecules involved in such immunologic responses. We have identified six genes encoding scabies mite homologues of mu and delta-like glutathione S-transferases (GSTs) as well as novel house dust mite GSTs. A mu class S. scabiei GST was subcloned into a prokaryotic expression system. The purified recombinant protein rSsGST01 reacted strongly with IgE and IgG4 in sera from crusted scabies patients. This response was not observed with control antigens or with ordinary scabies and uninfested patient sera. In addition, the specific IgE response to rSsGST01 did not correlate with the total IgE level of the patient. These results suggest that GST may play a role in the pathophysiology associated with crusted scabies.
机译：象鼻螨Sarcoptes scabiei是of疮的病原体，,疮是皮肤的高度传染性寄生虫病。尽管螨虫会引起明显的超敏反应，尤其是在结（（严重）ab疮中，但对于与这种免疫反应有关的特定ab螨虫分子知之甚少。我们已经确定了6个编码mu和delta样谷胱甘肽S-转移酶（GSTs）novel疮螨同源物以及新型屋尘螨GSTs的基因。将亩级S. scabiei GST亚克隆到原核表达系统中。纯化的重组蛋白rSsGST01与结s疮患者血清中的IgE和IgG4强烈反应。在对照抗原或普通sc疮和未感染患者血清中未观察到该反应。此外，对rSsGST01的特异性IgE反应与患者的总IgE水平无关。这些结果表明，GST可能在结cru疮相关的病理生理中起作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号