...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Therapeutic efficacy of quinine plus sulfadoxine-pyremethamine for the treatment of uncomplicated falciparum malaria in Bangladesh.
【24h】

Therapeutic efficacy of quinine plus sulfadoxine-pyremethamine for the treatment of uncomplicated falciparum malaria in Bangladesh.

机译：奎宁加磺胺多辛-乙胺嘧啶在孟加拉国治疗单纯性恶性疟疾的疗效。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In terms of drug resistance Bangladesh acts as an important gateway to the Indian Subcontinent. However, little is known about the current status of drug resistance in this country. The aim of this study was therefore to determine the therapeutic efficacy as well as in vitro drug sensitivity of quinine for 3 days plus a single dose of sulfadoxine/pyrimethamine (Q3F), an affordable alternative to the previously used chloroquine, for the treatment of uncomplicated falciparum malaria. Sixty-three patients were enrolled in the study; the overall cure rate in a 42-day follow-up after PCR adjustment was 87.3% (95% CI: 77.6-94.1). One patient was classified as early treatment failure (1.7%, 95% CI: 0.0-8.9%); 6 patients (10%; 95% CI: 3.8-20.5%) had late treatment failures within a median time of 27 days. HRP2 in vitro drug sensitivity tests were performed on all samples. Significantly higher (P = 0.008) in vitro IC(50)s for pyrimethamine in treatment failures reflect the somewhat compromised drug sensitivity to this drug. These data suggest that the combination of 3 days of quinine with a single dose of sulfadoxine/pyrimethamine is an interesting and affordable alternative as long as or whenever ACT is not available.
机译：在耐药性方面，孟加拉国是通往印度次大陆的重要门户。但是，对该国目前的耐药性知之甚少。因此，本研究的目的是确定奎宁3天的治疗效果以及体外药物敏感性，以及单剂量的磺胺多辛/乙胺嘧啶（Q3F）（可替代以前使用的氯喹的一种经济实惠的药物），用于治疗非复杂性恶性疟疾。六十三名患者被纳入研究。 PCR调整后的42天随访中，总治愈率为87.3％（95％CI：77.6-94.1）。一名患者被分类为早期治疗失败（1.7％，95％CI：0.0-8.9％）; 6名患者（10％; 95％CI：3.8-20.5％）在27天的中位时间内出现晚期治疗失败。对所有样品进行HRP2体外药物敏感性测试。乙胺嘧啶在治疗失败中的体外IC（50）s显着较高（P = 0.008），反映了对该药物的敏感性稍有下降。这些数据表明，只要没有ACT，只要有3天的奎宁与单剂量的磺胺多辛/乙胺嘧啶结合使用都是一种有趣且可负担的替代方案。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号