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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Stability of interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver stage antigen-1 and thrombospondin-related adhesive protein in residents of a malaria holoendemic area.
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Stability of interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver stage antigen-1 and thrombospondin-related adhesive protein in residents of a malaria holoendemic area.

机译：疟疾全流行地区居民对恶性疟原虫肝阶段抗原-1和血小板反应蛋白相关黏附蛋白的干扰素-γ和白介素10反应的稳定性。

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摘要

The stability of anti-malarial immunity will influence the interpretation of immunologic endpoints during malaria vaccine trials conducted in endemic areas. Therefore, we evaluated cytokine responses to Plasmodium falciparum liver stage antigen-1 (LSA-1) and thrombospondin-related adhesive protein (TRAP) by Kenyans from a holoendemic area at a 9-month interval. The proportion of adults with interferon-gamma (IFN-gamma) responses to 9-mer LSA-1 peptides was similar at both time-points, whereas responses from children decreased (P < 0.05). Response to the longer, 23-mer LSA-1 peptide was variable, decreasing in adults and children over time (P < 0.02 and P < 0.001, respectively). The proportion of children with IFN-gamma responses to either antigen at the second time-point was significantly lower than that of adults, yet more adults responded to 9-mer TRAP peptides (P < 0.02). In contrast, the proportion of interleukin-10 responses to LSA-1 and TRAP was similar at both time-points for both age groups. Most noteworthy was that even when the repeat cross-sectional frequency of cytokine responses was the same, these responses were not generated by the same individuals. This suggests that cytokine responses to LSA-1 and TRAP are transient under natural exposure conditions.
机译：在疟疾流行地区进行的疟疾疫苗试验期间，抗疟疾免疫的稳定性将影响免疫学终点的解释。因此，我们以9个月的间隔评估了肯尼亚人从全血统地区对恶性疟原虫肝阶段抗原1（LSA-1）和血小板反应蛋白相关粘附蛋白（TRAP）的细胞因子反应。在两个时间点，对9-mer LSA-1肽产生干扰素-γ（IFN-γ）反应的成人比例相似，而来自儿童的响应降低（P <0.05）。对更长的23聚体LSA-1肽的反应是可变的，成人和儿童随时间的推移而下降（分别为P <0.02和P <0.001）。在第二个时间点对任一抗原产生IFN-γ反应的儿童比例显着低于成年人，但更多的成年人对9聚体TRAP肽有反应（P <0.02）。相比之下，两个年龄段的两个时间点，白介素10对LSA-1和TRAP应答的比例均相似。最值得注意的是，即使细胞因子应答的重复截面频率相同，这些应答也不是由同一个人产生的。这表明在自然暴露条件下，细胞因子对LSA-1和TRAP的反应是短暂的。

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