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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Characterization of 'Yaa Chud' Medicine on the Thailand-Myanmar border: selecting for drug-resistant malaria and threatening public health.
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Characterization of 'Yaa Chud' Medicine on the Thailand-Myanmar border: selecting for drug-resistant malaria and threatening public health.

机译：泰国-缅甸边境的“ Yaa Chud”药物的特征：选择抗药性疟疾并威胁公众健康。

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摘要

Multidrug-resistant Plasmodium falciparum malaria is a severe public health problem on the Thailand-Myanmar border. Many villagers buy packets of 4-5 mixed medicines ("yaa chud") from shops without medical assessment as their first-line malaria treatment. In 2000-2001 a local researcher purchased 50 yaa chud from 44 shops around Mae Sot, Thailand and Myawaddy, Myanmar (Burma), for his wife who was said to be pregnant with fever and drowsiness. The tablets/capsules were provisionally identified by appearance and active ingredients determined in a subset by using mass and atomic spectrometry. The most frequently detected active ingredients were acetaminophen (22%), chlorpheniramine (13.4%), chloroquine (12.6%), tetracycline/doxycycline (11.4%), and quinine (5.1%). Only seven bags contained potentially curative medicine for malaria. A total of 82% of the bags contained medicines contraindicated in pregnancy. Inappropriate, ineffective antimalarial drugs on the Thailand-Myanmar border are likely to increase malaria morbidity, mortality and health costs and engender the emergence and spread of antimalarial drug resistance.
机译：耐多药恶性疟原虫疟疾是泰国-缅甸边界上的严重公共卫生问题。许多村民从商店购买了4-5包混合药品（“ yaa chud”），而没有经过医学评估，这是他们的一线疟疾治疗方法。在2000年至2001年间，一名当地研究人员从泰国湄索（Mae Sot）和缅甸米瓦底（缅甸）的44家商店购买了50 yaa chud，据说他的妻子患有发烧和嗜睡。通过使用质谱和原子光谱法通过外观和活性成分的暂时确定来确定片剂/胶囊剂。检出率最高的活性成分是对乙酰氨基酚（22％），扑尔敏（13.4％），氯喹（12.6％），四环素/强力霉素（11.4％）和奎宁（5.1％）。只有七个袋子装有可能治愈疟疾的药物。总计82％的袋子中装有孕妇禁忌的药物。在泰国-缅甸边界上使用不适当的，无效的抗疟药物可能会增加疟疾的发病率，死亡率和医疗费用，并导致抗疟药物耐药性的出现和传播。

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