...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Human CD8(+) T cells clear Cryptosporidium parvum from infected intestinal epithelial cells.
【24h】

Human CD8(+) T cells clear Cryptosporidium parvum from infected intestinal epithelial cells.

机译：人CD8（+）T细胞从感染的肠上皮细胞清除小隐孢子虫。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Intracellular protozoans of the genus Cryptosporidium are a major cause of diarrheal illness worldwide, especially in immunocompromised individuals. CD4(+) T cells and interferon-gamma are key factors in the control of cryptosporidiosis in human and murine models. Previous studies led us to hypothesize that CD8(+) T cells contribute to clearance of intestinal epithelial Cryptosporidium infection in humans. We report here that antigen expanded sensitized CD8(+) T cells reduce the parasite load in infected intestinal epithelial cell cultures and lyse infected intestinal epithelial cells. These effects are most likely mediated by the release of cytotoxic granules. Elimination of parasites seems to require antigen presentation through both human leukocyte antigen (HLA)-A and HLA-B. These data suggest that cytotoxic CD8(+) T cells play a role in clearing Cryptosporidium from the intestine, a previously unrecognized feature of the human immune response against this parasite.
机译：隐孢子虫属的细胞内原生动物是全世界腹泻病的主要原因，尤其是在免疫功能低下的人中。 CD4（+）T细胞和γ干扰素是人类和小鼠模型中隐孢子虫病控制的关键因素。先前的研究使我们假设CD8（+）T细胞有助于人类清除肠上皮隐孢子虫感染。我们在这里报告抗原扩展致敏的CD8（+）T细胞减少感染的肠上皮细胞培养物中的寄生虫负荷，并裂解感染的肠上皮细胞。这些作用很可能是由细胞毒性颗粒的释放介导的。消除寄生虫似乎需要通过人白细胞抗原（HLA）-A和HLA-B进行抗原呈递。这些数据表明，具有细胞毒性的CD8（+）T细胞在清除肠道隐孢子虫中起着作用，这是人类针对该寄生虫的免疫应答先前无法识别的特征。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号