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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Electrocardiographic Safety Evaluation of Dihydroartemisinin Piperaquine in the Treatment of Uncomplicated falciparum Malaria.
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Electrocardiographic Safety Evaluation of Dihydroartemisinin Piperaquine in the Treatment of Uncomplicated falciparum Malaria.

机译：双氢青蒿素哌拉喹治疗单纯性恶性疟疾的心电图安全性评估。

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摘要

Dihydroartemisinin-piperaquine (DP) could become a leading fixed combination malaria treatment worldwide. Although there is accumulating evidence of efficacy and safety from clinical trials, data on cardiotoxicity are limited. In two randomized controlled trials in Thailand, 56 patients had ECGs performed before treatment, 4 hours after the first dose, and 4 hours after the last dose. The mean (95% CI) changes in QTc interval (Bazett's correction) were 2 (-6 to 9) ms and 14 (7 to 21) ms, respectively. These small changes on the third day of treatment are similar to those observed elsewhere in the convalescent phase following antimalarial treatment with drugs known to have no cardiac effects and are therefore likely to result from recovery from acute malaria and not the treatment given. At therapeutic doses, DP does not have clinically significant effects on the electrocardiogram.
机译：双氢青蒿素-哌喹（DP）可能成为全球领先的固定组合疟疾治疗方法。尽管从临床试验中积累了有效性和安全性的证据，但有关心脏毒性的数据仍然有限。在泰国的两项随机对照试验中，有56例患者在治疗前，首次给药后4小时和最后一次给药后4小时进行了心电图检查。 QTc间隔（Bazett校正）的平均变化（95％CI）分别为2（-6至9）ms和14（7至21）ms。在治疗的第三天，这些小变化类似于使用已知对心脏没有影响的药物进行抗疟疾治疗后在恢复期的其他地方所观察到的那些变化，因此很可能是从急性疟疾的康复中获得的，而不是所给予的治疗。在治疗剂量下，DP对心电图没有临床显着影响。

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