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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Evidence for suppression of Onchocerca volvulus transmission in the Oaxaca focus in Mexico.
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Evidence for suppression of Onchocerca volvulus transmission in the Oaxaca focus in Mexico.

机译:墨西哥瓦哈卡州抑制盘尾丝虫传播的证据。

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摘要

Entomologic and serologic surveys were performed in four sentinel communities in the Oaxaca focus in southern Mexico to assess the level of transmission and exposure incidence to Onchocerca volvulus. All communities have been receiving ivermectin mass treatment twice per year since 1997. In one community, parasite DNA was detected by polymerase chain reaction-enzyme-linked immunosorbent assay in 2004 in one pool of 50 vector heads of 170 such pools (8,500 flies) examined, which indicated an estimated transmission potential of 6.7 third-stage larvae/person/year. No evidence for transmission was found in the three other communities in 13,650 flies examined. All persons in a cohort consisting of 117 children in the four communities remained serologically negative for antibodies recognizing a cocktail of recombinant antigens over a four-year period from 2001 to 2004, which indicated an exposure incidence of 0%. Taken together, these data suggest that transmission has been suppressed in the four communities.
机译:在墨西哥南部瓦哈卡州的四个哨点社区进行了昆虫学和血清学调查,以评估肠钉虫的传播和暴露水平。自1997年以来,所有社区都每年两次接受伊维菌素大规模治疗。在一个社区中,2004年通过聚合酶链反应-酶联免疫吸附测定法检测到寄生虫DNA,其中一个池中有50个载体头中的一个池,共检查了170个此类池(8,500苍蝇)。 ,这表明第三阶段幼虫/人/年的传播潜力约为6.7。在其他三个社区的13650例蝇中没有发现传播的证据。在这四个社区中,由117个儿童组成的一个队列中的所有人,在2001年至2004年的四年中,血清中抗体均阴性,这些抗体识别出重组抗原混合物,这表明暴露发生率为0%。综合来看,这些数据表明在四个社区中传播受到了抑制。

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