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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Evidence for stopping mass drug administration for lymphatic filariasis in some, but not all local government areas of Plateau and Nasarawa States, Nigeria
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Evidence for stopping mass drug administration for lymphatic filariasis in some, but not all local government areas of Plateau and Nasarawa States, Nigeria

机译：在尼日利亚高原地区和纳萨拉瓦州的部分但不是全部地方政府区域中，停止大量药物治疗淋巴丝虫病的证据

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摘要

An average of six annual rounds of ivermectin and albendazole were distributed in Plateau and Nasarawa States, Nigeria, to eliminate lymphatic filariasis. From 2007 to 2008, population-based surveys were implemented in all 30 local government areas (LGAs) of the two states to determine the prevalence of Wuchereria bancrofti antigenemia to assess which LGA mass drug administration (MDA) could be halted. In total, 36,681 persons from 7,819 households were examined for filarial antigen as determined by immunochromatographic card tests. Overall antigen prevalence was 3.05% (exact upper 95% confidence interval [CI] = 3.41%) with an upper 95% CI range by LGA of 0.50-19.3%. Among 3,233 children 6-7 years of age, overall antigen prevalence was 1.71% (exact upper 95% CI = 2.19%), too high to recommend generally halting MDA in the two-state area. However, based on criteria of < 2% antigenemia among persons > 2 years of age, stopping MDA was recommended for 10 LGAs.
机译：在尼日利亚的高原和纳萨拉瓦州，平均平均每年分发六轮伊维菌素和阿苯达唑，以消除淋巴丝虫病。从2007年到2008年，在这两个州的所有30个地方政府地区（LGAs）中进行了基于人群的调查，以确定Wuchereria bancrofti抗原血症的患病率，以评估可以停止哪种LGA大规模药物管理（MDA）。通过免疫色谱卡测试，总共检查了来自7,819户家庭的36,681人的丝状抗原。总体抗原患病率为3.05％（准确的上限95％置信区间[CI] = 3.41％），而LGA的上限95％CI范围为0.50-19.3％。在3233名6-7岁的儿童中，总体抗原发生率是1.71％（准确的较高95％CI = 2.19％），太高了以至于不能建议一般在两个州停止MDA。但是，根据2岁以下人群中<2％的抗原血症的标准，建议10例LGAs停止MDA。

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