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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Randomized, controlled, double-blind trial of daily oral azithromycin in adults for the prophylaxis of Plasmodium vivax malaria in Western Thailand.
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Randomized, controlled, double-blind trial of daily oral azithromycin in adults for the prophylaxis of Plasmodium vivax malaria in Western Thailand.

机译：成人每日口服阿奇霉素预防泰国西部间日疟原虫的随机，对照，双盲试验。

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摘要

We assessed the prophylactic efficacy of azithromycin (250 mg/day) against malaria in 276 adults in western Thailand in a randomized, double-blind, placebo-controlled trial. After antimalarial suppressive treatment, volunteers were randomized in a 2:1 ratio to either the azithromycin or placebo, respectively. Study medication was given for an average of 74 days. The azithromycin group (n = 179) had five endpoint parasitemias (1 Plasmodium vivax and 4 P. falciparum), and the placebo group (n = 97) had 28 endpoint parasitemias (21 P. vivax, 5 P. falciparum, and 2 mixed infections). Adverse events and compliance and withdrawal rates were similar in both groups. The protective efficacy (PE) of azithromycin was 98% for P. vivax (95% confidence interval [CI] = 88-100%). There were too few cases to reliably estimate the efficacy of azithromycin for P. falciparum (PE =71%, 95% C =-14-94%). We conclude that daily azithromycin was safe, well-tolerated, and had a high efficacy for the prevention of P. vivax malaria.
机译：在一项随机，双盲，安慰剂对照试验中，我们在泰国西部的276名成年人中评估了阿奇霉素（250毫克/天）对疟疾的预防效果。经过抗疟疾抑制治疗后，将志愿者分别以2：1的比例随机分配给阿奇霉素或安慰剂。研究药物平均给予74天。阿奇霉素组（n = 179）有5个端点寄生虫病（1个间日疟原虫和4个恶性疟原虫），而安慰剂组（n = 97）有28个端点寄生虫病（21个间日疟原虫，5个恶性疟原虫和2个混合性寄生虫病）感染）。两组的不良事件，依从性和戒断率相似。阿奇霉素对间日疟原虫的保护效力为98％（95％置信区间[CI] = 88-100％）。很少有病例能够可靠地估计阿奇霉素对恶性疟原虫的疗效（PE = 71％，95％C = -14-94％）。我们得出的结论是，每日阿奇霉素安全，耐受性好，对预防间日疟原虫疟疾具有很高的疗效。

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