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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Seasonality, malaria, and impact of prophylaxis in a West African village I. Effect of anemia in pregnancy.
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Seasonality, malaria, and impact of prophylaxis in a West African village I. Effect of anemia in pregnancy.

机译：西非村庄的季节性，疟疾和预防的影响I.贫血对怀孕的影响。

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The importance of malaria as a cause of anemia in pregnancy in endemic areas remains controversial. The prevalence of anemia in pregnant women following the dry (May) and the rainy (November) seasons was compared in two successive years in Bougoula village (region of Sikasso, Mali). Phase I (1992) was observational and included 172 pregnant women and 208 controls. In Phase II (1993, 174 pregnant women and 206 controls), malaria prophylaxis with proguanil (200 mg/day) and chloroquine (300 mg/week) was offered to pregnant women. A strong seasonal variation in the prevalence of moderate to severe anemia in pregnant women (hematocrit < 30%) occurred in Phase I (dry season = 8.7%, rainy season = 41.2%). This variation was present only in women of parity lower than five, and paralleled variation in parasitemia. In Phase II, the seasonal variation of anemia was suppressed in women under malaria prophylaxis (presence of antimalarial metabolites in urine), and the overall prevalence of moderate to severe anemiain pregnancy decreased by 55.5% (22.8-74.3%). We conclude that malaria is the major cause of anemia in pregnancy in this region. A high priority should be given to prevention of malaria in pregnancy.
机译：疟疾在地方病地区引起妊娠贫血的重要性仍然存在争议。在Bougoula村（马里Sikasso地区）连续两年比较了干旱（5月）和雨季（11月）后孕妇贫血的患病率。第一阶段（1992年）是观察性的，包括172名孕妇和208名对照。在第二阶段（1993年，有174名孕妇和206名对照），向孕妇提供了预防性的疟疾预防，包括使用鸟嘌呤（200 mg /天）和氯喹（300 mg /周）。在第一阶段（旱季= 8.7％，雨季= 41.2％），孕妇中度至重度贫血的患病率（血细胞比容<30％）出现强烈的季节性变化。这种变化仅出现在五岁以下的女性中，并且寄生虫病的变化也与此平行。在第二阶段，预防疟疾（尿液中存在抗疟疾代谢物）的妇女贫血的季节性变化得到抑制，怀孕中中度至重度贫血的总体患病率降低了55.5％（22.8-74.3％）。我们得出结论，疟疾是该地区妊娠贫血的主要原因。应高度重视预防妊娠疟疾。

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