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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Humoral response to defined Plasmodium falciparum antigens in cerebral and uncomplicated malaria and their relationship to parasite genotype.
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Humoral response to defined Plasmodium falciparum antigens in cerebral and uncomplicated malaria and their relationship to parasite genotype.

机译：对脑部和单纯性疟疾中确定的恶性疟原虫抗原的体液反应及其与寄生虫基因型的关系。

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摘要

The prevalence and concentration of IgG antibodies to defined Plasmodium falciparum antigens were assessed in serum samples of 97 children with cerebral malaria and 146 children with uncomplicated malaria. The antigens used included the schizont extract, ring-infected erythrocyte surface antigen, the C-terminal region of merozoite surface antigen-1 (MSA-1) (BVp42), and three recombinant proteins of MSA-2 (FC27, 3D7, and d3D7). Parasite isolates from 24 children with cerebral malaria and 22 children with uncomplicated malaria were genotyped for MSA-1 and MSA-2. The distribution of parasite genotypes belonging to the different allelic families was similar in both the cerebral and uncomplicated malaria groups. There were higher antibody levels to antigens derived from the infecting parasite genotype than to heterologous genotypes, but this difference was only statistically significant for antibody against the d3D7 antigen among children infected with the 3D7 parasite genotype (mean log = 4.72 versus 3.45 antibody units [AU]; P = 0.029). Those who died were more likely to be infected with the FC27 genotype and had lower antibody levels to MSA-2 of the 3D7 type than had cerebral malaria patients who survived (mean log = 2.94 versus 3.79 AU; P = 0.049). Antibodies against parasites of the 3D7 genotype are associated with a better prognosis among children with cerebral malaria partly because these children are more likely to be infected with parasites of this genotype rather than the FC27 genotype, which appears to be more virulent.
机译：在97例脑型疟疾患儿和146例简单性疟疾患儿的血清样本中评估了针对确定的恶性疟原虫抗原的IgG抗体的存在和浓度。使用的抗原包括裂殖体提取物，环感染的红细胞表面抗原，裂殖子表面抗原-1（MSA-1）（BVp42）的C末端区域和MSA-2的三种重组蛋白（FC27、3D7和d3D7） ）。对来自24名患有脑疟疾的儿童和22名患有单纯性疟疾的儿童的寄生虫分离株进行了MSA-1和MSA-2基因分型。属于不同等位基因家族的寄生虫基因型在脑型和非复杂型疟疾组中的分布相似。来自感染寄生虫基因型的抗原的抗体水平高于异源基因型，但是在感染3D7寄生虫基因型的儿童中，针对d3D7抗原的抗体这一差异仅具有统计学意义（平均对数= 4.72对3.45抗体单位[AU] ]; P ＝ 0.029）。与幸存的脑疟疾患者相比，死亡的患者更有可能感染FC27基因型，并且对3D7型MSA-2的抗体水平较低（平均对数= 2.94对3.79 AU; P = 0.049）。在患有脑疟疾的儿童中，针对3D7基因型寄生虫的抗体与更好的预后相关，部分原因是这些儿童更容易感染这种基因型的寄生虫，而不是FC27基因型，后者似乎更具毒性。

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