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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Relationship between circulating antigen level and morbidity in Schistosoma mansoni-infected children evaluated by ultrasonography.
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Relationship between circulating antigen level and morbidity in Schistosoma mansoni-infected children evaluated by ultrasonography.

机译：超声检查评估曼氏血吸虫感染儿童的循环抗原水平与发病率之间的关系。

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摘要

Ninety-eight Schistosoma mansoni-infected children from an endemic area in Sharkia Governorate, Egypt were evaluated by abdominal ultrasonography to determine liver and spleen sizes, grade of periportal fibrosis, and splenic vein diameter. Circulating antigen levels were measured using a double sandwich ELISA in which the sensitivity was 91.8% and specificity was > 99%, with no evidence of cross-reactivity with other parasites. No significant relationship was observed between antigen level and clinical stages of the disease as assessed by physical examination (P > 0.05). When ultrasound was used to stage disease, the mean antigen level was significantly higher among hepatosplenic cases than intestinal cases (P < 0.05). No difference in mean antigen levels were found between the splenic and hepatic cases. Furthermore, a direct correlation (P < 0.01) was observed between antigen level and disease severity as monitored by ultrasonography. Antigen level showed a positive correlation with the degree of periportal fibrosis (P < 0.05). Moreover, a significant increase in the percent of children who were antigen positive (> 80 ng/ml) was found in those with more severe periportal fibrosis (P < 0.001). The findings suggest that ultrasonography along with measurement of circulating antigen levels predict morbidity in schistosomiasis mansoni.
机译：通过腹部超声检查评估了埃及Sharkia省一个地方病地区的98个曼氏血吸虫感染的儿童，以确定肝脏和脾脏的大小，门静脉纤维化的程度以及脾静脉直径。使用双夹心ELISA测量循环抗原水平，其敏感性为91.8％，特异性> 99％，没有与其他寄生虫交叉反应的证据。体格检查未发现抗原水平与疾病的临床分期之间存在显着相关性（P> 0.05）。当使用超声对疾病进行分期时，肝脾病例中的平均抗原水平显着高于肠道病例（P <0.05）。在脾和肝病例之间未发现平均抗原水平的差异。此外，超声检查发现抗原水平与疾病严重程度之间存在直接相关性（P <0.01）。抗原水平与门静脉纤维化程度呈正相关（P <0.05）。此外，发现在患有更严重的门静脉周围纤维化的儿童中，抗原阳性（> 80 ng / ml）的儿童百分比显着增加（P <0.001）。这些发现表明，超声检查和循环抗原水平的测量可预测曼氏血吸虫病的发病率。

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