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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Chlamydia on children and flies after mass antibiotic treatment for trachoma.
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Chlamydia on children and flies after mass antibiotic treatment for trachoma.

机译：沙眼衣原体对儿童和果蝇进行大规模抗生素治疗后可治疗沙眼。

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摘要

There are various approaches to control trachoma. These include the elimination of the ocular strains of Chlamydia trachomatis that cause the disease and to decrease the spread of infection by other measures such as fly control. Here, we examined how these two are related (i.e., how treating children with antibiotics affects carriage of Chlamydia by flies). Flies were collected in villages that had received mass oral azithromycin distribution and were compared with flies in untreated villages. Polymerase chain reaction (PCR) was performed to detect chlamydial DNA on the flies. Conjunctival swabs were also taken to assay for chlamydial prevalence in the children. Chlamydia was found on 23% of the flies in the untreated villages but only 0.3% in treated villages. Prevalence of trachoma in children proved to be an excellent predictor of the prevalence on flies (correlation coefficient, 0.89). Thus, treating children with antibiotics may drastically reduce the role of flies as a vector.
机译：有多种控制沙眼的方法。这些措施包括消除引起该疾病的沙眼衣原体眼部劳损，并通过其他措施（例如蝇控制）减少感染的传播。在这里，我们检查了这两者之间的关系（即用抗生素治疗儿童如何影响苍蝇的衣原体运输）。在大量接受阿奇霉素口服液的村庄收集果蝇，并将其与未经处理的村庄的果蝇进行比较。进行聚合酶链反应（PCR）以检测果蝇中的衣原体DNA。结膜拭子还用于检测儿童衣原体感染率。在未经治疗的村庄中，有23％的蝇类中发现了衣原体，但是在经过治疗的村庄中，只有0.3％的蝇类中有衣原体。儿童沙眼的患病率被证明是果蝇患病率的极好的预测指标（相关系数为0.89）。因此，用抗生素治疗儿童可能会大大降低苍蝇作为媒介的作用。

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