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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >A comparison of sulfadoxine-pyrimethamine with chloroquine and pyrimethamine for prevention of malaria in pregnant Nigerian women.
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A comparison of sulfadoxine-pyrimethamine with chloroquine and pyrimethamine for prevention of malaria in pregnant Nigerian women.

机译：磺胺多辛-乙胺嘧啶与氯喹和乙胺嘧啶预防尼日利亚孕妇疟疾的比较。

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摘要

Few studies have documented the effectiveness in west Africa of intermittent preventive treatment of malaria with sulfadoxine-pyrimethamine (SP) in pregnancy. Pregnant Nigerian women were assigned to receive either SP given twice or presumptive chloroquine (CQ) treatment followed by weekly pyrimethamine (CQ + P); 250 were enrolled in each group. Of those completing follow-up, 4 (1.8%) in the SP group and 22 (9.8%) in the CQ + P groups had a febrile illness (P = 0.005). None in the SP group but 11 (4.9%) in the CQ + P group had peripheral parasitemia prior to or during delivery (P = 0.002). Two (1.2%) in the SP group and 9 (5.0%) in the CQ + P group were anemic at delivery (P = 0.04). There were six low birth weight infants in the SP group and eight in the CQ + P group (P = 0.21). Intermittent preventive treatment with SP is superior to CQ + P for prevention of malaria and anemia in pregnant women in Nigeria.
机译：很少有研究证明在西非用磺胺多辛-乙胺嘧啶（SP）间歇性预防疟疾的有效性。尼日利亚孕妇分两次接受SP或接受氯喹（CQ）治疗，然后每周接受乙胺嘧啶（CQ + P）治疗;每组250人。在完成随访的患者中，SP组有4例（1.8％），CQ + P组有22例（9.8％）患有高热病（P = 0.005）。 SP组中没有一个，但CQ + P组中有11个（4.9％）在分娩前或分娩期间有外周寄生虫病（P = 0.002）。 SP组有两个（1.2％）和CQ + P组有9个（5.0％）在分娩时贫血（P = 0.04）。 SP组有6例低出生体重儿，CQ + P组有8例（P = 0.21）。在尼日利亚，预防SP的间歇性预防治疗优于CQ + P预防疟疾和贫血。

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