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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Nonmalarial acute undifferentiated fever in a rural hospital in central India: diagnostic uncertainty and overtreatment with antimalarial agents.
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Nonmalarial acute undifferentiated fever in a rural hospital in central India: diagnostic uncertainty and overtreatment with antimalarial agents.

机译：印度中部乡村医院的非疟疾急性未分化发热：诊断不确定性和抗疟疾药物过度治疗。

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摘要

Nonmalarial acute undifferentiated fever (NMAUF) refers to a febrile illness with no indication of an organ-specific disease after diagnosis of malaria has been excluded. In developing countries, the empirical treatment of NMAUFs with antimalarial drugs continues even in the era of highly specific rapid diagnostic tests (RDTs) for malaria. We carried out a retrospective review of patients with fever admitted to a rural teaching hospital in central India. We categorized patients with NMAUF into different clinical syndromes and determined their demographic profile, inhospital course, and the pattern of antimalarial use. The study sample included 1,197 adult patients who were investigated for malaria; 1,053 (88%) of them had NMAUF, and use of further diagnostics in this group was limited. Despite one or more negative tests for malaria, many patients (39.9%, 95% CI 37.0-43.3) received antimalarial drugs. These results suggest a need for guidelines and training to improve empirical treatment of NMAUF.
机译：非疟疾急性未分化发热（NMAUF）是指在排除疟疾诊断后没有任何器官特异性疾病迹象的发热性疾病。在发展中国家，即使在针对疟疾的高度特异性快速诊断测试（RDT）时代，仍继续使用抗疟药对NMAUF进行经验性治疗。我们对印度中部农村教学医院收治的发烧患者进行了回顾性研究。我们将NMAUF患者分为不同的临床综合征，并确定了他们的人口统计学特征，住院过程和抗疟疾使用模式。该研究样本包括1,197名接受过疟疾调查的成年患者。其中1,053（88％）人患有NMAUF，并且该组中进一步诊断的使用受到限制。尽管对疟疾进行了一项或多项阴性测试，但许多患者（39.9％，95％CI 37.0-43.3）接受了抗疟药。这些结果表明需要指南和培训来改善NMAUF的经验治疗。

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