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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Short report: Decreased intensity of inflammation in benznidazole-treated mice inoculated with Trypanosoma cruzi I stocks from Mexico and persistence of circulating parasites
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Short report: Decreased intensity of inflammation in benznidazole-treated mice inoculated with Trypanosoma cruzi I stocks from Mexico and persistence of circulating parasites

机译：简短报告：接种来自墨西哥的克鲁斯锥虫I储备液接种苯并硝唑处理的小鼠的炎症强度降低，并且持续存在寄生虫

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摘要

We analyzed the intensity of inflammation and parasitism in BALB/c mice infected with Trypanosoma cruzi I stocks from Mexico with and without benznidazole treatment in the acute phase of disease. Heart and skeletal muscles were evaluated for parasites and inflammation and blood was evaluated for persistence of circulating parasites. Parasitemia was influenced by T. cruzi stocks used and benznidazole treatment. This treatment cleared circulating parasites three days after starting treatment when monitored by directmicroscopy. There was a significant reduction of inflammation in skeletal muscles after benznidazole treatment in animals infected with Mexican T. cruzi I stocks (P < 0.05), but this reduction was not significant in the heart (P > 0.05). Trypanosoma cruzi I parasites from Mexico were demonstrated by polymerase chain reaction in tissues and blood of animals after benznidazole treatment.
机译：我们分析了在疾病急性期感染了或未使用苯并硝唑的墨西哥克鲁斯锥虫I种群感染的BALB / c小鼠的炎症和寄生虫的强度。对心脏和骨骼肌的寄生虫和炎症进行了评估，对血液中循环寄生虫的持久性进行了评估。寄生虫病受到所使用的克鲁氏锥虫种群和苯硝唑处理的影响。当通过直接显微镜监测时，该处理在开始处理后三天清除了循环寄生虫。苯并硝唑治疗后，感染墨西哥克氏锥虫I种群的动物的骨骼肌炎症显着减少（P <0.05），但在心脏中这种减少并不明显（P> 0.05）。苯并硝唑处理后动物体内组织和血液中的聚合酶链反应证明了来自墨西哥的锥虫锥虫。

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