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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Reduced risk of uncomplicated malaria episodes in children with alpha+-thalassemia in northeastern Tanzania.
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Reduced risk of uncomplicated malaria episodes in children with alpha+-thalassemia in northeastern Tanzania.

机译：降低坦桑尼亚东北部患有α+地中海贫血的儿童发生单纯性疟疾的风险。

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摘要

The prevalence of human red blood cell (RBC) polymorphisms is high in areas of intense Plasmodium falciparum transmission, and individuals carrying these genetic traits are believed to be partially protected against severe malaria. However, it remains uncertain how RBC polymorphisms affect the susceptibility to uncomplicated malaria. We compared the risk of suffering from febrile, uncomplicated malaria between individuals carrying three common RBC polymorphisms (sickle cell trait, alpha(+)-thalassemia, and glucose-6-phosphate-dehydrogenase deficiency) and controls. The study was performed in an area of intense malaria transmission where 202 individuals 0-19 years of age were monitored clinically for a period of 6 months. RBC polymorphisms were assessed with molecular methods, and plasma antibodies to P. falciparum variant surface antigens (anti-VSA IgG) and glutamate-rich protein (anti-GLURP IgG) were measured with flow cytometry and ELISA assays, respectively. Regression analyses showed that alpha(+)-thalassemia was associated with a reduced risk of uncomplicated malaria episodes and that this advantageous effect seemed to be more predominant in children older than 5 years of age, but was independent of levels of antibodies to VSA and GLURP.
机译：人类红细胞（RBC）多态性在恶性疟原虫传播频繁的地区很高，据信具有这些遗传特征的个体可以部分预防严重的疟疾。然而，仍不确定RBC多态性如何影响对简单疟疾的易感性。我们比较了携带三种常见RBC多态性（镰刀状细胞性状，α（+）-地中海贫血和葡萄糖-6-磷酸-脱氢酶缺乏症）的人与对照组患高热，简单疟疾的风险。该研究在严重的疟疾传播地区进行，该地区对202名0-19岁的个体进行了6个月的临床监测。使用分子方法评估RBC多态性，并分别通过流式细胞术和ELISA测定抗恶性疟原虫表面抗原的血浆抗体（抗VSA IgG）和富含谷氨酸的蛋白质（抗GLURP IgG）。回归分析表明，α（+）地中海贫血与单纯性疟疾发作的风险降低相关，并且这种有利作用似乎在5岁以上的儿童中更为普遍，但与VSA和GLURP抗体水平无关。

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