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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Resistance to chloroquine by Plasmodium vivax at Alor in the Lesser Sundas Archipelago in eastern Indonesia.
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Resistance to chloroquine by Plasmodium vivax at Alor in the Lesser Sundas Archipelago in eastern Indonesia.

机译：印度尼西亚东部小苏打斯群岛的亚罗尔的间日疟原虫对氯喹的抗药性。

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摘要

The therapeutic response to standard chloroquine therapy against Plasmodium vivax was evaluated in 36 subjects living at Alor in the Lesser Sundas Archipelago of eastern Indonesia. Chloroquine level were measured on 32 individuals, and showed evidence of adequate absorption of standard chloroquine therapy. Three subjects failed treatment by Day 2 or 3, with evidence of rising asexual parasitemia, and two others had stable parasitemia to Day 7. Ten more subjects had recurrent parasitemia by Day 14, two by Day 21, and another one by Day 28. Three subjects had recurrent parasitemia on Days 14 and 28, but with chloroquine < 100 ng/mL. Eleven subjects cleared parasitemia by Day 3 and had no recurrences up to Day 28. In summary, 28-day cumulative incidence of confirmed resistance to chloroquine was 56% of infections evaluated. Chloroquine should not be considered adequate for treatment of acute vivax malaria acquired in this region.
机译：在印度尼西亚东部小苏打斯群岛的亚罗（Alor）居住的36名受试者中评估了对间日疟原虫标准氯喹疗法的治疗效果。测量了32名个体的氯喹水平，并显示出标准氯喹疗法可充分吸收的证据。 3名受试者在第2或3天治疗失败，并显示出无性寄生虫病的增加，另外2名在第7天出现了稳定的寄生虫病。另有10名受试者在第14天出现了复发性寄生虫病，两名在第21天出现了寄生虫病，另一名在28天出现了寄生虫病。受试者在第14天和第28天出现复发性寄生虫病，但氯喹<100 ng / mL。到第3天，有11名受试者清除了寄生虫病，直到第28天都没有复发。总而言之，确诊对氯喹耐药的28天累积发生率是所评估感染的56％。氯喹不应被认为足以治疗该地区获得的急性间日疟疾。

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