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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Case report: Possible links between sickle cell crisis and pentavalent antimony
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Case report: Possible links between sickle cell crisis and pentavalent antimony

机译：病例报告：镰状细胞危机与五价锑之间的可能联系

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摘要

For over 60 years, pentavalent antimony (Sb v) has been the first-line treatment of leishmaniasis. Sickle cell anemia is a disease caused by a defect in red blood cells, which among other things can cause vasooclusive crisis. We report the case of a 6-year-old child with leishmaniasis who during treatment with meglumine antimoniate developed a sickle cell crisis (SCC). No previous reports describing the relationship between antimonial drugs and sickle cell disease were found. Reviews of both the pathophysiology of SCC and the mechanism of action of Sb v revealed that a common pathway (glutathione) may have resulted in the SCC. ChemoText, a novel database created to predict chemical-protein-disease interactions, was used to perform a more expansive and systematic review that was able to support the association between glutathione, Sb v, and SCC. Although suggestive evidence to support the hypothesis, additional research at the bench would be needed to prove Sb v caused the SCC.
机译：五十多年来，五价锑已成为利什曼病的一线治疗方法。镰状细胞性贫血是一种由红细胞缺陷引起的疾病，其中，红细胞缺陷可能导致血管收缩性危机。我们报告了一个6岁的利什曼病儿童的案例，他在接受葡甲胺锑酸盐治疗期间发生了镰状细胞危机（SCC）。以前没有发现描述抗生素与镰状细胞病之间关系的报道。对SCC的病理生理学和Sb v的作用机理的评论均表明，可能是导致SCC的常见途径（谷胱甘肽）。 ChemoText是创建用来预测化学-蛋白质-疾病相互作用的新型数据库，用于进行更广泛和系统的综述，能够支持谷胱甘肽，Sb v和SCC之间的关联。尽管有支持这一假说的暗示性证据，但仍需要在替补席上进行其他研究以证明Sb v引起SCC。

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