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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Detection of persistent West Nile virus RNA in experimentally and naturally infected avian hosts
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Detection of persistent West Nile virus RNA in experimentally and naturally infected avian hosts

机译：在实验和自然感染的禽类宿主中检测持久性西尼罗河病毒RNA

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To determine whether West Nile virus (WNV) persistent infection in avian hosts may potentially serve as an overwintering mechanism, House Sparrows and House Finches, experimentally and naturally infected with several strains of WNV, and two naturally infected Western Scrub-Jays were held in mosquito-proof outdoor aviaries from 2007-March 2008. Overall, 94% (n = 36) of House Sparrows, 100% (n = 14) of House Finches and 2 Western Scrub-Jays remained WNV antibody positive. When combined by species, 37% of the House Sparrows, 50% of the House Finches, and 2 Western Scrub-Jays were WNV RNA positive at necropsy, up to 36 weeks post-infection. Infectious WNV was not detected. Our study supports the hypothesis that some avian hosts support the long-term persistence of WNV RNA, but it remains unresolved whether these infections relapse to restart an avian-arthropod transmission cycle and thereby serve as an overwintering mechanism for WNV.
机译：为了确定西尼罗河病毒（WNV）在禽类寄主中的持续感染是否可能是越冬的机制，实验上和自然感染了几株WNV的麻雀和雀雀和两只自然感染的Western Scrub-Jays被关在蚊子中2007年3月至2008年3月的防鸟舍。总体而言，94％（n = 36）的麻雀，100％（n = 14）的雀雀和2个Western Scrub-Jays仍保持WNV抗体阳性。当按物种组合时，在尸体剖检时，感染后长达36周，37％的麻雀，50％的雀雀和2个西方Scrub-Jays的WNV RNA阳性。未检测到传染性WNV。我们的研究支持以下假设：一些禽类宿主支持WNV RNA的长期持久性，但这些感染是否复发以重新启动禽类节肢动物传播周期并因此成为WNV的越冬机制，这一点仍未解决。

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