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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >No evidence for spread of Plasmodium falciparum artemisinin resistance to Savannakhet Province, Southern Laos
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No evidence for spread of Plasmodium falciparum artemisinin resistance to Savannakhet Province, Southern Laos

机译：没有证据表明恶性疟原虫青蒿素对老挝南部沙湾拿吉省的抗药性传播

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摘要

We conducted an open-label, randomized clinical trial to assess parasite clearance times (PCT) and the efficacy of 4 mg/kg (group 1, n = 22) and 2 mg/kg (group 2, n = 22) of oral artesunate for three days followed by artemetherlumefantrine in patients with uncomplicated Plasmodium falciparum malaria at Xepon Interdistrict Hospital, Savannakhet Province in southern Laos. Slides were read in duplicate. The overall mean (95% confidence interval; range) PCT in hours was 23.2 (21.2-25.3; 12-46) and 22.4 (20.3-24.5; 12-46) for the first and second microscopists, respectively (P = 0.57). Ten (23%) patients remained parasitemic on day 1 after treatment (4 [18%] in group 1 and 6 [27%] in group 2; P = 0.47). No patient had patent asexual parasitemia on the second and third days of treatment. The 42-day polymerase chain reaction-corrected cure rates were 100% in both treatment groups. Serious adverse events did not develop during or after treatment in any patients. In conclusion, no evidence of P. falciparum in vivo resistance to artesunate was found in southern Laos.
机译：我们进行了一项开放标签的随机临床试验，以评估寄生虫清除时间（PCT）和4 mg / kg（第1组，n = 22）和2 mg / kg（第2组，n = 22）口服青蒿琥酯的疗效在老挝南部萨凡纳赫特省Xepon Interdistrict医院，对患有并发恶性疟原虫疟疾的患者进行了为期三天的青蒿琥酯治疗。重复读取幻灯片。第一名和第二名显微镜检查者的小时总PCT平均平均值（95％置信区间;范围）为23.2（21.2-25.3; 12-46）和22.4（20.3-24.5; 12-46）（P = 0.57）。在治疗后的第1天，有十名（23％）患者保持寄生虫病发生（第1组4 [18％]，第2组6 [27％]; P = 0.47）。在治疗的第二天和第三天，没有患者患有无性生殖器寄生虫病。在两个治疗组中，经42天聚合酶链反应校正的治愈率均为100％。在任何患者中或治疗后均未发生严重不良事件。总之，在老挝南部没有发现恶性疟原虫在体内对青蒿琥酯有抗药性的证据。

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