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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Short report: Phylogenetic analysis of dengue virus types 1 and 4 circulating in Puerto Rico and Key West, Florida, during 2010 epidemics
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Short report: Phylogenetic analysis of dengue virus types 1 and 4 circulating in Puerto Rico and Key West, Florida, during 2010 epidemics

机译：简短报告：2010年流行期间在波多黎各和佛罗里达基韦斯特传播的1型和4型登革热病毒的系统发育分析

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摘要

We describe sequences of six strains of dengue virus (DENV): three DENV-1 isolates and two DENV-4 isolates from Puerto Rico, and a DENV-1 strain from Key West, Florida, obtained from blood donors during 2010 epidemics. Phylogenetic analysis revealed that the Puerto Rico DENV-1 strains constitute a new lineage within genotype V different from those that circulated in Puerto Rico during the past two decades. The newer Puerto Rico DENV-1 strains associated with strains from the Caribbean and South America. The DENV-1 strain from Key West, Florida clustered with a strain isolated from mosquito pools collected in that area and with a number of strains from Nicaragua and Mexico circulating during 2006-2009. The Puerto Rico DENV-4 isolates of genotype II associated with strains that have circulated on the island throughout the 1980s and 1990s and with strains from the Caribbean region and Central America. Introduction and circulation of novel DENV lineages in dengue-endemic regions have the potential to increase the severity of dengue cases.
机译：我们描述了六株登革热病毒（DENV）的序列：三个DENV-1分离株和两个来自波多黎各的DENV-4分离株，以及一个来自佛罗里达州基韦斯特的DENV-1株，在2010年流行期间从献血者那里获得。系统发育分析表明，波多黎各DENV-1菌株在基因型V中构成了一个新的谱系，与过去二十年来在波多黎各传播的那些不同。较新的波多黎各DENV-1菌株与来自加勒比海和南美的菌株有关。来自佛罗里达州基韦斯特的DENV-1菌株与从该地区收集的蚊帐中分离出的菌株以及2006-2009年期间传播的来自尼加拉瓜和墨西哥的许多菌株聚集在一起。波多黎各DENV-4基因型II分离株与在整个1980年代和1990年代在岛上流行的菌株以及加勒比地区和中美洲的菌株有关。在登革热流行地区引入和传播新型DENV血统有可能增加登革热病例的严重性。

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